3 citations
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December 2021 in “IntechOpen eBooks” This article reviews the potential of bionanomaterials, derived from natural biomolecules, for wound healing and reports no new clinical results; it emphasizes the need for further research in this area.
11 citations
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June 2025 in “Advanced Functional Materials” This study reports that a pH-responsive nanosilver platform improved wound healing in mouse and rabbit models by targeting bacteria and supporting tissue repair more effectively than traditional silver nanoparticles.
129 citations
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July 2019 in “Stem Cell Research & Therapy” This review examines the role of epidermal stem cells in wound healing, discussing their characteristics and mechanisms, but does not report new clinical results.
2 citations
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November 2025 in “International Journal of Molecular Sciences” This review highlights that the skin microbiota plays a crucial role in wound healing, with beneficial microorganisms aiding tissue repair and opportunistic pathogens hindering it, potentially guiding future microbiome-targeted therapies.
September 2025 in “International Journal of Biological Macromolecules” In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.
April 2026 in “IntechOpen eBooks” This study reviews the complexities of burn-related skin complications, highlighting postburn pruritus, dyspigmentation, and the risk of malignant ulcers, while offering a framework for evidence-based management through various treatment approaches.
April 2026 in “Clinical Cosmetic and Investigational Dermatology” This review highlights the varied therapeutic applications of punch-based techniques in dermatologic surgery, noting consistent evidence for follicular unit extraction in androgenetic alopecia, but more mixed results for scar treatment, vitiligo, and chronic wounds, warranting further standardized research.
September 2023 in “Clinical, cosmetic and investigational dermatology” In this case report, a rare form of chronic cutaneous lupus, lupus erythematosus profundus, was treated effectively with topical and systemic therapies, leading to improvement and healing of ulcerations, though resulting in atrophic scars and macules.
9 citations
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November 2024 in “Journal of Wound Management Official journal of the European Wound Management Association” Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.
April 2005 in “Clinics in Plastic Surgery” This review discusses the use of lasers in plastic surgery for various conditions and reports no new clinical results; the authors note effective treatment options for patients across different ethnic backgrounds.
134 citations
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October 2020 in “Preprints.org” This review discusses recent advancements in platelet-rich plasma therapies for tissue repair and regenerative medicine, but reports no new clinical results, highlighting a need for translating research into human clinical protocols.
26 citations
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September 2024 in “National Science Review” This review outlines guidelines for designing Janus hydrogel bioadhesives, highlighting their potential to enhance clinical applications in tissue repair and regenerative medicine by mimicking natural biological barriers, although challenges remain in optimizing their asymmetric surface designs.
October 2023 in “Journal of Advanced Sciences” This review highlights PRF's potential as a regenerative medicine tool, detailing its diverse applications in dentistry, orthopedics, and dermatology, but presents no new clinical results.
December 2025 in “Sensors” In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.
In this study, researchers analyzed the waters of Ladakh's hotsprings, identifying 27 bioactive compounds with potential health benefits, but emphasize that further clinical trials are needed to confirm their therapeutic efficacy and safety.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
14 citations
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February 2020 in “Stem Cells International” This study reported that a single local subcutaneous infusion of mesenchymal stromal cells from the human umbilical cord promoted wound healing, improved blood circulation, and reduced wound size in patients with chronic wounds without significant adverse effects over one year.
9 citations
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August 2021 in “Biological Chemistry” This review examines current and potential approaches to managing chronic wound inflammation through macrophage-targeted strategies using ECM-inspired wound dressings, but it reports no new clinical results.
2 citations
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April 2018 in “Journal of Investigative Dermatology” This study defines two types of RDEB wounds, chronic open and recurrent, and finds that patient self-reports on wound size correlate well with investigator measurements when complemented by serial photography.
February 2026 in “BMC Plastic and Reconstructive Surgery” This review suggests that induced pluripotent stem cells (iPSCs) hold promise for treating chronic wounds, but further work is needed to address safety, efficacy, and translation from preclinical models to real-world applications.
70 citations
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February 2021 in “International Journal of Molecular Sciences” This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.
25 citations
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January 2018 in “Acta Clinica Croatica” This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.
May 2017 in “Journal of The American Academy of Dermatology” LED light helps human hair root cells grow and prevents them from dying by activating specific growth pathways.
February 2026 in “Bioimpacts” This review discusses advancements and challenges in using 3D bioprinting for diabetic foot ulcer treatments, highlighting potential improvements and existing limitations in replicating skin architecture and clinical application.
1 citations
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January 2025 in “Advances in Dermatology and Allergology” In this animal study, PRF enhanced the repair of chronic wounds in rats by reducing inflammation and promoting collagen deposition and new blood vessel formation, potentially through activating the Wnt/β-catenin signaling pathway.
41 citations
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October 2024 in “Nature Communications” In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.
August 2023 in “International journal of medical science and clinical research studies” This review discusses platelet-rich plasma (PRP) therapy for pediatric surgical wound care, evaluating its potential as an adjunctive treatment, but reports no new clinical results.
April 2026 in “Applied Materials Today” This study introduced a pH-responsive polymeric wound dressing that enhances healing in chronic wounds by changing shape and drug delivery based on wound pH, achieving a 94.88% healing rate in diabetic mice by day 14.
22 citations
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April 2022 in “Stem cell research & therapy” This study found that extracellular vesicles derived from hair follicle mesenchymal stromal cells demonstrated similar potential to those from adipose tissue in promoting cell proliferation and migration, enhancing angiogenesis, and protecting cells under stress, suggesting promise for chronic wound treatment.
1 citations
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November 2023 in “Biomaterials advances” This study found that combining mesenchymal stromal cells from adipose tissue and hair follicles with soy protein and β-chitin scaffolds significantly reduced wound healing time and improved skin regeneration in vivo.