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The document shows the state of pharmaceutical patents as of 1999, focusing on treatments for various diseases.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Oral spironolactone and isotretinoin are effective for treating acne.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

COVID-19 leaves 80% of patients with long-term symptoms like fatigue and headaches.

Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Testosterone therapy increases bone density in older men with low testosterone levels.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Rotterdam Study aims to understand various diseases in older adults.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Some medicinal plants can help heal wounds and may lead to new treatments.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.

Hair loss linked to higher heart disease risk in both men and women.

The Protein-Sparing Modified Fast is effective for rapid weight loss and maintaining it, but requires medical supervision and can have side effects.

Ginseng is possibly safe but its effectiveness is unclear due to poor quality studies and mixed results.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Some people who recover from COVID-19 continue to have symptoms like fatigue and cough for over 120 days, and some experience hair loss about 59 days after getting sick.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Tamsulosin for enlarged prostate may increase the risk of severe low blood pressure, especially when starting or restarting the medication.