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Glossary Ceramides

lipid molecules crucial for skin barrier and moisture retention

Ceramides are lipid molecules found in high concentrations within cell membranes, particularly in the outermost layer of the skin. They play a crucial role in maintaining the skin's barrier function and retaining moisture, which helps protect against environmental damage and dehydration. In the context of hair, ceramides help to strengthen the hair shaft and maintain its integrity, reducing breakage and enhancing overall hair health.

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research Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

7 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

This study suggests that synthetic ceramides may promote hair growth by inducing proliferation of human dermal papilla cells through modulation of Wnt/β-catenin and BMP2/4 signaling pathways.

research Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling

53 citations , February 2015 in “Journal of Investigative Dermatology”

This study found that inactivating CerS4 in mice led to hair follicle stem cell exhaustion and hair loss, indicating its role in regulating hair regeneration through ceramide composition and signaling pathways.

research Promotion of hair growth by newly synthesized ceramide mimetic compound

8 citations , July 2017 in “Biochemical and biophysical research communications”

This study reported that the pseudoceramide bis-oleamido isopropyl alcohol (BOI) promotes hair growth in ex vivo cultured human hair follicles, likely by enhancing sphingolipid synthesis in dermal papilla cells.

research LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

211 citations , March 2011 in “Journal of Lipid Research”

This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.

research Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

67 citations , April 2014 in “Biochemical Journal”

This study found that mice deficient in ceramide synthase 4 showed altered sebum composition and progressive hair loss due to obstructed hair canals.

research Ceramide binding to African–American hair fibre correlates with resistance to hair breakage

45 citations , February 2002 in “International Journal of Cosmetic Science”

This study found that a ceramide derived from sphinganine can bind to African–American hair, reducing breakage when applied in a shampoo after relaxing treatments.

research Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis

15 citations , February 2020 in “Journal of Investigative Dermatology”

Ceramide Synthase 4 is crucial for healthy skin barrier function.

research Ceramide: A New Approach to Hair Protection and Conditioning.

10 citations , January 1994 in “Cosmetics and toiletries”

This study reports on the vulnerability of hair's structural lipids to physical and chemical damage and describes properties of hair treated with a synthesized ceramide derivative.

research Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

research Damaged hair retrieval with ceramide-rich liposomes.

2 citations , July 2012 in “PubMed”

In this study, the use of internal wool lipid liposomes was shown to improve the lipid composition and increase the resistance to breaking in both untreated and chemically treated hair fibers.

Skin Barrier, Phenotypic and Genotypic Characterization of Autosomal Recessive Ichthyosis in TGM1-Deficient Jack Russell Terriers and Response to Topical Ceramide

research Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide

August 2024 in “Veterinary Dermatology”

This study reported that topical ω‐0‐acylceramide improved skin barrier function in Jack Russell Terriers with TGM1-deficient autosomal recessive congenital ichthyosis, normalizing skin pH and reducing transepidermal water loss.

research P133 : Case-control study: the effects of synthetic ceramide on dandruff, erythema, sebum secretion and water loss of scalp

January 2019 in “프로그램북(구 초록집)”

This study found that synthetic ceramide shampoo improved dandruff and erythema while reducing water loss when compared to control in a group of 20 subjects over four weeks.

research 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function

April 2018 in “Journal of Investigative Dermatology”

This study found that inactivating CerS4 in mouse epidermis disrupts lipid homeostasis and is crucial for maintaining, but not forming, the skin barrier.

research Stress-induced senescence of dermal papilla cells restored by synthesized ceramide

September 2017

This study suggests that ceramide may help maintain hair follicles under stress by modulating growth factor pathways in senescence-induced dermal papilla cells.

research 277 Stress-induced senescence of dermal papilla cells restored by synthesized ceramide

September 2017 in “Journal of Investigative Dermatology”

Ceramide may help delay hair aging by restoring stressed hair cells.

research P164 : The effect of ceramide-based essence cream for the damaged hair shaft

January 2018 in “프로그램북(구 초록집)”

This study found that ceramide-based essence cream, particularly those with stearyl and stearyl-cholesterol, improved the ultrastructure of damaged hair cuticles.

research Ceramide synthase 4 is involved in the regulation of hair follicle stem cell homeostasis

January 2015 in “Kölner Universitäts PublikationsServer (Universität zu Köln)”

research Montagna Symposium 2017—Precision Dermatology: Next Generation Prevention, Diagnosis, and Treatment

1 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This meeting synopsis on the 66th Annual Montagna Symposium reports no new results but outlines discussions on precision dermatology, integrating molecular insights with clinical applications for personalized skin care.

research Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease Treatments

April 2016 in “Journal of Investigative Dermatology”

This symposium reviewed various topics in stem cell research related to skin biology, including mechanisms of skin regeneration, tumorigenesis, and pathways influencing melanoma stem cell behavior, but it reported no new clinical results.

research 666 Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in follicular dystrophy and primary cicatricial alopecia

April 2018 in “Journal of Investigative Dermatology”

Mutations in Far2 mice cause hair loss due to sebaceous gland issues.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome: A Review

research The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review

1 citations , January 2023 in “Metabolites”

This review discusses the relationship between gut microbiota and polycystic ovarian syndrome (PCOS), including its potential mechanisms and the role of alterations in microbiome composition on PCOS pathophysiology.

research Risk factors and lipid metabolism characteristics of early‐onset male androgenetic alopecia: A pilot study

May 2024 in “Journal of cosmetic dermatology”

This study found that early-onset male androgenetic alopecia is associated with abnormal lipid metabolism and lower levels of certain serum markers, which may serve as risk factors or protective factors for the condition.

research Molecular characterization of xerosis cutis: A systematic review

33 citations , December 2021 in “PLoS ONE”

This review summarized multiple molecular markers studied for their association with dry skin, finding considerable variability and uncertainty about which markers best indicate xerosis cutis.

research Application of Nanoemulsions in Cosmetics

23 citations , January 2018 in “Elsevier eBooks”

This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.

research Exploring Physiological Differences in Injury Response by Skin Tone: A Scoping Review

February 2025 in “Journal of Tissue Viability”

This scoping review suggests that physiological differences in skin structure may affect how individuals with different skin tones respond to pressure ulcer development, emphasizing the need for targeted prevention strategies.

research Nanoemulsions for the Encapsulation of Hydrophobic Actives

June 2021 in “Zenodo (CERN European Organization for Nuclear Research)”

This study reported the preparation of stable oil-in-water nanoemulsions that effectively incorporate ceramide-like molecules and minoxidil, suggesting these formulations may enhance distribution and availability of hydrophobic compounds in cosmetic applications.

research Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment

4 citations , January 2025 in “The Journal of Cell Biology”

This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.

research Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, the researchers found that deleting ceramide synthase 4 in the skin's epidermis alters stem cell differentiation, disrupting hair follicle structure and barrier function, potentially leading to immune responses similar to atopic dermatitis.

research Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents

88 citations , July 2001 in “British journal of dermatology/British journal of dermatology, Supplement”

This study reported that antimicrobial and topical retinoid therapies led to significant changes in the lipid profiles of sebaceous follicular infundibulum, with increased triglycerides and ceramide subfractions observed.