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This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.

This study found that by using an automated system to analyze skin histology, 108 structural features were significantly affected by age, and it identified four new aging biomarkers and notable sex-based differences in skin aging.

This structural study reports on the crystal properties of a compound used for treating alopecia, revealing different conformations and nitrogen hybridization in its piperidine rings.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

In a rabbit model, this study found that the AMFIBHA skin substitute promoted wound healing and regeneration of skin structures in large-area third-degree burn wounds, suggesting potential clinical use.

This study found that Raman spectroscopy has potential for detecting biophysical differences in basal cell carcinoma compared to normal skin structures, supporting its future use in Mohs surgery.

This study found that while 3D spheroid culture preserved sweat gland cell-specific markers better than 2D culture, their growth and structural organization were suboptimal, highlighting the need for improved culture systems.

In this study, a porous keratin hydrogel derived from wool hair demonstrated strong mechanical properties and supported the growth of various animal cells, indicating potential as a scaffold in tissue engineering.

This study found that deleting the FoxN1 gene in mice disrupted the 3D thymic epithelial structure and led to 2D epithelial cysts, revealing its crucial role in thymus organization but not causing athymia.

This microscopy study examined the non-keratinous regions of human hair fibers, revealing detailed morphology that could help understand how external influences affect hair structure.

This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.

This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.

This study found that sympathetic nerves and arrector pili muscles form a niche that modulates hair follicle stem cell activity, revealing their role in hair follicle regeneration.

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

This study concluded that dilated cardiomyopathy in Ctsl-deficient mice is mainly due to the lack of cathepsin L in cardiomyocytes, with additional heart stress from the fur defect.

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

This article discusses the importance of understanding the skin's structure and function for comprehending both healthy skin biology and skin disease pathophysiology, but reports no new findings.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

This study describes the anatomy of arrector pili muscles in scalp hair follicular units, proposing a model where a single muscle structure is shared by all follicles within a unit.

The researchers reported that exposure to long days after short-day treatment induced a synchronized, out-of-season wool growth cycle in New Zealand Wiltshire sheep, similar to cycles induced in other species.

In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.

This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.

This study analyzes the fine structure and protein distribution in monotreme hairs, finding similarities with other mammals and detailing unique immunocytochemical features in their inner root sheaths.

This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

This study confirms previous observations that benign lipogenic lesions may contain eccrine/apocrine glandular components, potentially due to adipocytic proliferation entrapping glandular structures.

In this study, targeted overexpression of the BMP receptor ALK2 in mouse hair follicle stem cells altered follicle structure and impaired cutaneous wound healing.

This study found that the keratin expression in basal cell carcinoma resembles that of the pilosebaceous apparatus, with uniform presence of certain keratins in all cases.

This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.