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In this study, researchers used quantitative fate mapping to investigate how the infundibulum, part of the epidermis, is maintained during adulthood, finding that progenitors maintain this tissue through stochastic cell fate choices, with cells at the bottom providing transient support during hair growth phases.

This study investigated how 2D and 3D cell culturing methods influence hair follicle morphogenesis, finding that 3D cultures responded more expectedly to minoxidil while 2D cultures reacted better to DHT treatment, challenging the assumption that 3D cultures are always superior.

Understanding skin structure and development helps diagnose and treat skin disorders.

This study identified a proliferative intermediate transcriptional state associated with the transition from secondary hair germ cells to lower hair follicle-associated cells during early hair follicle regeneration in mice.

This study used an ex vivo human skin model to show that tropical conditions disrupt skin homeostasis, resulting in epidermal thickening and junctional flattening, and found that Kombucha tea extract may help preserve skin structure under such stress.

This study found that high-concentration cell-free adipose extract effectively reduced collagen deposition and blood vessel formation in a rabbit ear model, showing promise for preventing and treating hypertrophic scars.

This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.

This study found that conditional deletion of CD271 in mouse epidermis led to significant disorganization and increased thickness, suggesting CD271's crucial role in regulating skin differentiation and structure.

This study found that excessive consumption of cloves in mice caused toxic changes in the liver, including structural damage and cell death, but concluded these effects are not considered dangerous.

This review discusses how combining single-cell RNA sequencing and 3D bioprinting is advancing skin tissue engineering by enhancing cellular-level precision and addressing challenges like vascularization, ultimately improving regenerative outcomes and therapeutic strategies.

This review synthesizes recent molecular and preclinical advances in alopecia areata and androgenetic alopecia, highlighting how interventions targeting specific intracellular signaling pathways and utilizing stem cell technologies can support precision regrowth and structural follicle reconstruction.

This study demonstrated that a ligand-independent action of the vitamin D receptor significantly affects keratinocyte behavior in hair follicles and skin, pointing to its crucial role in maintaining normal hair and skin structures in rats.

In this study of folliculitis decalvans, researchers found that compound follicular structures in scalp biopsies are primarily composed of terminal anagen follicles, surrounded by fibrosis and inflammatory cell infiltrate, which could enhance understanding of this condition.

This study reports that different adhesion molecules play distinct roles in the morphogenesis of feathers and hair, influencing processes such as mesenchymal condensation, epithelial folding, and cell death.

This study observed distinct changes in the ultrastructure of Hexi cashmere goat hair follicles throughout the year, highlighting stages with specific cellular and structural characteristics.

This study demonstrates that the trichohyalin gene is located at chromosomal region 1q21, where several other genes related to epidermal differentiation also map.

This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.

This study suggests that CD151-integrin complexes inhibit epithelial cell migration, and that disruption of these complexes enhances migration, regulated by Rho GTPase activation differences on distinct laminins.

This study introduced a simple and reliable in vitro assay capable of large-scale simultaneous screening of hair growth-promoting compounds using a 3D co-culture system of human dermal papilla and outer root sheath cells.

This review synthesizes current advances in transcriptomics and RNA regulatory networks, alongside stem cell-derived skin organoid research, to propose a conceptual framework for understanding and potentially guiding regenerative skin repair, without claiming clinical readiness.

This study confirmed the localization of CK19 and vimentin in skin cells, with CK19 linked to hair growth and vimentin stabilizing fibroblast structure.

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.

This study found that nevoid basal cell carcinomas originate in the epidermis and upper hair follicles, resembling early nonnevoid basal cell carcinoma proliferations.

The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.

The study concluded that fatty acid transport protein 4 in epidermal keratinocytes is crucial for maintaining normal skin structure, as its deficiency led to hyperkeratosis and epidermal barrier disruption in mice.

This case report describes a 28-year-old man with widespread pigmented basal cell carcinomas and recurrent infections that were challenging to control, associated with nevus comedonicus and a rudimentary toe.

This study found that cultured papilla cells can induce follicle formation and hair growth when combined with different epidermal and dermal cells, highlighting their powerful inductive properties and potential for dermatological applications.

Calretinin identifies the companion cell layer in human hair follicles.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.