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Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Herbal remedies can cause adverse effects and need more safety research.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

The study found that in Latin America, ancestry varies by location, influences physical traits, and affects how people perceive their own heritage.

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The method can effectively extract biomedical information without needing expert annotation, performing better than previous models.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The Rotterdam Study aims to understand various diseases in older adults.