Search
for

    Glossary Castration-Resistant Prostate Cancer

    cancer that grows despite low testosterone levels

    Castration-Resistant Prostate Cancer (CRPC) is a type of prostate cancer that continues to progress despite the reduction of testosterone to very low levels, typically achieved through medical or surgical means (castration). This form of cancer is particularly challenging to treat because it no longer responds to therapies that lower testosterone, a hormone that usually fuels prostate cancer growth.

    Related Terms

    Sort by

    Research 30 of 743

    1. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    2. Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer Medical Oncology · 2013 · 6 citations
    3. Low-Dose Dimethyl Sulfoxide (DMSO) Suppresses Androgen Receptor (AR) and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer (CRPC) Cells Therapeutics · 2025
    4. Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer Cancers · 2024
    5. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    6. Redefining hormone resistance in prostate cancer Therapeutic Advances in Medical Oncology · 2009 · 38 citations
    7. HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond Endocrinology · 2019 · 30 citations
    8. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    9. Abiraterone and spironolactone in prostate cancer: a combination to avoid Acta Clinica Belgica · 2018 · 9 citations
    10. Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry 2017 · 22 citations
    11. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    12. Editorial: Androgen-dependent diseases and their treatment Frontiers in Endocrinology · 2024
    13. New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics Frontiers in Oncology · 2023
    14. Endocrinology of the Aging Prostate: Current Concepts Frontiers in Endocrinology · 2021 · 21 citations
    15. Highlights of This Issue Cancer Epidemiology Biomarkers & Prevention · 2011
    16. Hormone Blocking Anticancer Drugs 2015
    17. Therapeutic Strategies to Target the Androgen Receptor Journal of Medicinal Chemistry · 2022 · 36 citations
    18. Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer International Journal of Molecular Sciences · 2020 · 45 citations
    19. Doxetaxel: new indication. Prostate cancer: a few more weeks. PubMed · 2006
    20. Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review Expert opinion on therapeutic patents · 2017 · 70 citations
    21. Alternative androgen pathways WikiJournal of Medicine · 2023
    22. Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes SPIRE - Sciences Po Institutional REpository · 2023
    23. The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model Biology direct · 2010 · 50 citations
    24. Relation of urinary stone disease with androgenetic alopecia and serum testosterone levels Urolithiasis · 2016 · 6 citations
    25. Is dehydroepiandrosterone a hormone? Journal of Endocrinology · 2005 · 403 citations
    26. Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment Cancer · 2025 · 3 citations
    27. 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice European Urology · 2013 · 7 citations
    28. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression Korean Journal of Urology · 2014 · 75 citations
    29. Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer Communications biology · 2020 · 113 citations
    30. Androgen Deprivation Therapy in Prostate Cancer: Focusing on Sexual Side Effects The Journal of Sexual Medicine · 2012 · 35 citations