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Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Spin traps like PBN could protect skin from pollution and sunlight in cosmetics but need more research for safe use.

Thallium, mercury, selenium, and colchicine strongly cause hair loss.

Chitrak is a medicinal plant with health benefits like fighting microbes, reducing inflammation, and promoting hair growth, but it can be toxic and needs more research.

Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

Finasteride may lower cholesterol and slow heart disease progression.

Hydroxychloroquine and chloroquine are not recommended for COVID-19 treatment due to insufficient evidence and safety concerns.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Minoxidil improves blood flow in heart failure patients.

Onions may help reduce cancer risk and obesity-related issues.

Dates may improve heart health, fight infections, protect kidneys, reduce inflammation, support pregnancy, promote dental and bone health, enhance mental function, and have anti-cancer properties, and are also beneficial for skin and hair care.

Statins may be linked to reproductive organ conditions, and their risks should be monitored.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Mycophenolate mofetil may improve lupus nephritis remission more than cyclophosphamide but with uncertain safety.

Acyzol could help treat conditions caused by zinc deficiency.

Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.

Sulforaphane from broccoli may help treat certain cancers, hormone issues, and hair loss.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Terbinafine is more effective than itraconazole for toenail fungus, especially in older patients, and debridement improves its effectiveness.

Simvastatin/ezetimibe did not effectively treat severe alopecia areata and caused side effects in some patients.

Certain skin diseases are linked to Agent Orange and similar chemicals; veterans should be screened and informed about uncertain risks, and current data doesn't link spironolactone with breast cancer.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

The weight loss drug Orlistat can cause liver damage and should be used with caution, especially in those with liver or kidney issues.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

New therapies are being developed that target integrin pathways to treat various diseases.

New hair follicle-targeting treatments show promise for hair disorders but need more research on safety and effectiveness.

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.