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    Glossary Cardiac Hypertrophy

    thickening of heart muscle due to increased workload

    Cardiac Hypertrophy, also known as Myocardial Hypertrophy, is the thickening of the heart muscle, specifically the myocardium. This condition can result from increased workload on the heart due to high blood pressure or other cardiovascular diseases, leading to an enlarged heart that may struggle to pump blood efficiently. While it can be a compensatory response to increased demand, prolonged hypertrophy can lead to heart failure and other complications.

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    1. Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction Circulation · 2015 · 56 citations
    2. Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring Cardiovascular Research · 2019 · 21 citations
    3. Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood Journal of Endocrinological Investigation · 2023 · 2 citations
    4. Targeting cardiac hypertrophy through a nuclear co‐repressor EMBO molecular medicine · 2019 · 3 citations
    5. Gender Differences in Cardiac Hypertrophy Journal of Cardiovascular Translational Research · 2020 · 27 citations
    6. Abstract 153: Inhibition of the 5-a-reductase Reduces Cardiac Hypertrophy and Improves Cardiac Function Circulation Research · 2013
    7. Testosterone, cytochrome P450, and cardiac hypertrophy The FASEB Journal · 2002 · 155 citations
    8. Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice PLOS ONE · 2013 · 18 citations
    9. Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage Figshare · 2020
    10. Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents bioRxiv (Cold Spring Harbor Laboratory) · 2022
    11. Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage Brazilian Journal of Pharmaceutical Sciences · 2020
    12. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008 · 1533 citations
    13. Anabolic-androgenic steroids and cardiovascular risk Chinese Medical Journal · 2019 · 38 citations
    14. The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia Pharmacology Research & Perspectives · 2020 · 6 citations
    15. Anabolic-Androgenic Steroids and Cardiometabolic Derangements Cureus · 2021 · 2 citations
    16. Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology Frontiers in Cardiovascular Medicine · 2025 · 1 citations
    17. Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice Journal of Molecular and Cellular Cardiology · 2018 · 13 citations
    18. Exploring in vitro markers of potency of extracellular vesicles from cardiosphere-derived cells in the treatment of cardiac ageing European Heart Journal · 2022
    19. Dihydrotestosterone—a culprit in left ventricular hypertrophy International Journal of Cardiology · 2012 · 4 citations
    20. Anabolic-androgenic steroids. Mechanism of action and clinical effects Journal of Education Health and Sport · 2023 · 1 citations
    21. Cardiac Amyloidosis and Aortic Stenosis: When to Consider it and How to Treat it? ABC Heart Failure & Cardiomyopathy · 2021
    22. DNA Damage Response Mediates Pressure Overload–Induced Cardiomyocyte Hypertrophy Circulation · 2019 · 42 citations
    23. Anti-androgenic therapy with finasteride in patients with chronic heart failure – a retrospective propensity score based analysis Scientific Reports · 2019 · 7 citations
    24. Spatial Gene Profiling in the Ischemic Heart Circulation · 2017 · 1 citations
    25. A case report and brief literature review of Klippel-Trénaunay syndrome Research and reports in neonatology · 2012
    26. Editorial: Growth and Tissue Regeneration with focus on Proteoglycans Frontiers in Cell and Developmental Biology · 2023
    27. Anabolic androgenic steroids impact on cardiovascular risk and cardiovascular events. The literature review Quality in Sport · 2026
    28. Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity Molecular Pharmaceutics · 2010 · 102 citations
    29. Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat Hypertension · 2013 · 28 citations
    30. Improved Cardiovascular Effects of a Novel Pomegranate Byproduct Extract Obtained through Hydrodynamic Cavitation Nutrients · 2024 · 18 citations