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GlossaryCalcium-Binding Protein 1

regulates intracellular calcium levels crucial for cellular processes

Calcium-Binding Protein 1 (CaBP1) is a protein that plays a crucial role in regulating calcium levels within cells. It binds to calcium ions, which is essential for various cellular processes such as muscle contraction, neurotransmitter release, and cell signaling. This protein is particularly important in the nervous system, where it helps modulate the activity of calcium channels and other proteins involved in neuronal communication.

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Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1

research Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1

November 2022

Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.

research Significance of the S100A4 Protein in Psoriasis

45 citations , January 2010 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

research Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles

4 citations , January 2017 in “Biological & pharmaceutical bulletin”

Inhibiting ALOX12 can help hair cuticle maturation by increasing S100A3 citrullination.

research Calcium regulation of stem cells

25 citations , May 2020 in “EMBO reports”

Calcium is important for stem cell function and maintenance, especially in blood and skin cells.

research Vitamin D Receptor: New Assignments for an Already Busy Receptor

510 citations , December 2006 in “Endocrinology”

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

research Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle

7 citations , January 2009 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research Minireview: vitamin D receptor: new assignments for an already busy receptor. - eScholarship

December 2006

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations , October 2008 in “Endocrine reviews”

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Label-free proteomics to identify keratins and keratin-associated proteins and their effects on the fleece traits of Inner Mongolia Cashmere Goats

research Label-free proteomics to identify keratins and keratin-associated proteins and their effects on the fleece traits of Inner Mongolia Cashmere Goats

January 2023 in “Czech Journal of Animal Science”

Proteins influence the quality and traits of cashmere goat fleece, affecting hair strength and diameter.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

19 citations , July 2020 in “EBioMedicine”

A gene variant increases the risk of a type of hair loss by affecting hair protein production.

research Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

3 citations , August 2020 in “Animals”

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( <i>Capra hircus</i> )

research Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( Capra hircus )

11 citations , January 2018 in “Royal Society Open Science”

Scientists found genes linked to the growth of high-quality brush hair in Chinese Haimen goats.

In silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia

research In silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia

6 citations , September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

research Pharmacotherapy for Keloids and Hypertrophic Scars

April 2024 in “International journal of molecular sciences”

Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.

research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation

25 citations , October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

A direct link between<i>Prss53</i>, hair curvature, and skeletal dysplasia

research A direct link betweenPrss53, hair curvature, and skeletal dysplasia

February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Prss53 affects hair shape and bone development in rabbits.

Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments

research Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments

38 citations , February 2012 in “Analytical biochemistry”

Hair proteins have weak spots in their α-helical segments.

research Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation

27 citations , September 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

The alopecia areata phenotype is induced by the water avoidance stress test in <i>cchcr1</i>-deficient mice

research The alopecia areata phenotype is induced by the water avoidance stress test in cchcr1-deficient mice

December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.

Review of Hair Follicle Dermal Papilla cells as <i>in vitro</i> screening model for hair growth

research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

76 citations , October 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice

research Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice

48 citations , May 2015 in “NPJ microgravity”

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

research Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales

5 citations , January 2022 in “Scientific reports”

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

research Calreticulin: non‐endoplasmic reticulum functions in physiology and disease

341 citations , November 2009 in “The FASEB Journal”

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling

9 citations , May 2012 in “PLOS ONE”

ILK is essential for skin development, pigmentation, and healing.