Search

for
Search:

Glossary Calcium

vital mineral essential for bones, teeth, and muscle function

Calcium is a vital mineral found in many foods and is essential for various bodily functions, including building and maintaining strong bones and teeth. It also plays a crucial role in muscle contraction, blood clotting, and nerve signal transmission. For professionals, it's important to note that calcium homeostasis is tightly regulated by hormones such as parathyroid hormone (PTH) and vitamin D, which ensure proper absorption and utilization in the body.

Related Terms

Sort by

Research

30 / 1000+ results

research Cytoplasmic free calcium distributions during the development of root hairs of Arabidopsis thaliana

317 citations , August 1997 in “The Plant Journal”

This study observed that while calcium influx does not initiate root hairs in Arabidopsis thaliana, it may be crucial for sustaining their elongation through elevated calcium levels at the root hair tip.

research Root hair growth in Arabidopsis thaliana is directed by calcium and an endogenous polarity

200 citations , November 1997 in “Planta”

This study found that while a tip-focused calcium gradient influences localized growth in root hairs and pollen tubes, it is not the primary determinant of growth direction in root hairs of Arabidopsis thaliana.

research The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

161 citations , June 1993 in “Journal of Biological Chemistry”

This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.

research Arabidopsis CNGC14 Mediates Calcium Influx Required for Tip Growth in Root Hairs

93 citations , March 2017 in “Molecular Plant”

This study concluded that CNGC14 is a calcium-permeable channel crucial for polarized tip growth in Arabidopsis root hairs, but other channels may also influence the observed calcium influx.

research Vitamin D and calcium regulation of epidermal wound healing

86 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study suggests that vitamin D and calcium signaling play a crucial role in wound healing by regulating stem cell activation through enhanced β-catenin transcriptional activity in mice.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

This study suggests that S100A4 and S100A6 proteins may play key roles in activating stem cells for hair follicle regeneration in mice.

research Sodium chloride reduces growth and cytosolic calcium, but does not affect cytosolic pH, in root hairs of Arabidopsis thaliana L.

69 citations , March 2003 in “Journal of Experimental Botany”

This study found that salinity stress in Arabidopsis thaliana root hairs may inhibit hair extension through changes in the tip-focused Ca(2+) gradient, while cytosolic pH remains unaffected.

research Multiple cyclic nucleotide‐gated channels coordinate calcium oscillations and polar growth of root hairs

56 citations , April 2019 in “The Plant Journal”

This study found that CNGC 6, CNGC 9, and CNGC 14 are crucial for maintaining calcium oscillations necessary for normal root hair growth in plants, with mutations leading to defects like swelling and bursting.

research Light Sheet Fluorescence Microscopy Quantifies Calcium Oscillations in Root Hairs ofArabidopsis thaliana

56 citations , March 2017 in “Plant and Cell Physiology”

This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.

research The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene

50 citations , February 2004 in “Genomics”

This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.

research Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo

46 citations , May 2003 in “Mechanisms of Development”

This study found that overexpression of the calcium sensing receptor in transgenic mice accelerates epidermal differentiation and hair growth, suggesting its role in enhancing calcium signaling and interaction with other pathways.

research Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing

44 citations , January 2021 in “Research”

This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.

research Ultrastructural Localization of S100A3, a Cysteine-rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-freezing Immunocytochemistry

40 citations , April 1999 in “Journal of Histochemistry & Cytochemistry”

In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.

research Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review

39 citations , June 2023 in “Frontiers in Medicine”

This review found limited but suggestive evidence that Calcium Hydroxylapatite may promote skin regeneration through increased collagen production, cell proliferation, and angiogenesis, although most studies had methodological limitations.

research Proliferation and Differentiation of Cultured Human Keratinocytes is Modulated by 1,25(OH)₂D₃ and Synthetic Vitamin D₃ Analogues in a Cell Density‐, Calcium‐ and Serum‐Dependent Manner*

39 citations , January 1997 in “Pharmacology & toxicology”

This study found that human keratinocytes' sensitivity and response to vitamin D3 analogues vary based on cell density, serum availability, and calcium concentration.

research Evidence for various calcium sites in human hair shaft revealed by sub-micrometer X-ray fluorescence

31 citations , December 2002 in “Biochimica et biophysica acta. G, General subjects/Biochimica et biophysica acta. General subjects (Online)”

This study identified two types of calcium in human scalp hair, with one type highly variable between individuals, potentially impacting the analysis of environmental and medical factors related to hair calcium.

research Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17

31 citations , March 2010 in “Molecular Endocrinology”

This study identified that androgens increase calcium sensitization in mouse colonic smooth muscle by activating the Rho/Rho kinase pathway, highlighting its role in modulating muscle contractility.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization

28 citations , March 2017 in “Endocrinology”

In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.

research Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory.

26 citations , April 1977 in “PubMed”

This report notes that five women experiencing hypertrichosis as a side effect of minoxidil had successful hair removal using a calcium thioglycolate depilatory agent.

research Calcium regulation of stem cells

25 citations , May 2020 in “EMBO reports”

This review discusses the potential roles of calcium in the regulation of pluripotent and tissue-specific stem cells but reports no new experimental results, highlighting areas for future research.

research The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation

24 citations , March 2016 in “Journal of Investigative Dermatology”

This study suggests that TIP39 and its receptor PTH2R, identified in human epidermis, may play a role in keratinocyte function and influence skin differentiation.

research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

23 citations , October 2021 in “Cell Stem Cell”

This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.

research Lead, cadmium, copper, zinc, iron, and calcium in human hair as a function of gender, age, smoking, and hair dyeing

22 citations , November 2010 in “Toxicological & Environmental Chemistry Reviews”

In this study, higher concentrations of Pb, Cd, Cu, and Zn were found in the hair of smokers and users of hair dyes compared to non-smokers and those with undyed hair.