5 citations
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January 2014 in “Asian Journal of Chemistry” This study developed a simple and cost-effective chromatographic method for simultaneously analyzing betamethasone dipropionate and calcipotriol, achieving rapid separation within 7 minutes suitable for routine applications.
5 citations
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January 1995 in “Journal of Dermatological Treatment” This study suggests that topical calcipotriol did not significantly enhance hair growth when combined with SADBE in patients with severe alopecia areata.
3 citations
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March 2019 in “Fayoum University Medical Journal/Fayoum University Medical Journal ” In this study, topical calcipotriol was found to be more effective than oral vitamin D for improving mild to moderate alopecia areata, with a 68% improvement rate and no correlation between serum vitamin D levels and treatment efficacy.
2 citations
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October 2021 in “QJM” This study found that both CO2 laser combined with topical methotrexate and calcipotriol plus betamethasone treatments improved nail psoriasis similarly, but some symptoms showed no improvement.
2 citations
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December 1973 in “Calcified tissue research” This study proposed a hypothesis for cutaneous calcinosis, suggesting that feeding DHT and subsequent epilation lead to ATP release and calcium orthophosphate formation, initiating calcification in rats.
1 citations
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May 2024 in “Journal of Pakistan Association of Dermatologists” This study found that topical calcipotriol was significantly more effective than topical tacrolimus in promoting hair growth for alopecia areata patients, demonstrating 67% efficacy compared to 33% efficacy with tacrolimus over a 6-month period.
1 citations
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December 2022 in “Journal of cosmetic dermatology” This study found that combining a potent steroid with a vitamin D analogue may offer more convenient treatment for localized alopecia areata than using a superpotent steroid alone, with comparable efficacy but fewer side effects.
1 citations
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January 2021 in “Journal of clinical and diagnostic research” In this study, adding topical calcipotriol 0.005% to topical clobetasol 0.05% significantly improved treatment efficacy for Alopecia Areata compared to using clobetasol alone, as evidenced by a greater reduction in SALT scores over 24 weeks.
1 citations
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April 2009 in “Expert Review of Dermatology” This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
January 2026 in “Annals of Dermatology” In this study, 80% of pediatric patients with alopecia areata treated with calcipotriol/betamethasone ointment showed hair regrowth over 12 weeks, suggesting it may be an effective option, though 20% had no improvement or worsening symptoms.
December 2025 in “Cureus” In this case report, a 40-year-old woman with systemic lupus erythematosus developed calcinosis cutis, a rare complication characterized by calcified deposits in her legs, requiring surgical intervention and ongoing medical treatment due to infection.
September 2025 in “Journal of Skin and Stem Cell” This study found that combining topical calcipotriol with intralesional autologous PRP injection significantly reduced Severity of Alopecia Tool scores in patients with alopecia areata, more effectively than either treatment alone.
July 2025 in “Journal of Investigative Dermatology” May 2025 in “JEADV Clinical Practice” This study found that using calcipotriene and betamethasone dipropionate cream in a real-world setting significantly improved clinical outcomes and patient quality of life for adults with mild-to-moderate scalp psoriasis, especially among those with higher adherence, demonstrating high treatment satisfaction.
February 2025 in “Indian Dermatology Online Journal” The study found that both mometasone and calcipotriol ointments effectively reduced alopecia severity in localized alopecia areata, with calcipotriol having fewer side effects, while tacrolimus showed no significant effect.
January 2025 in “Journal of Cutaneous Medicine and Surgery” In this clinical trial, adding topical calcipotriol to intralesional triamcinolone acetonide significantly increased hair regrowth efficacy in scalp alopecia areata patches compared to steroids alone, but not in beard patches, with a lower incidence of atrophy observed.
January 2025 in “SKIN The Journal of Cutaneous Medicine” This study suggests that while vitamin D3 deficiency is linked to alopecia areata severity, evidence for the effectiveness of supplementation or topical calcipotriol treatment remains inconsistent and low quality.
September 2024 in “Journal of the American Academy of Dermatology” Early intervention is important for limited systemic sclerosis patients due to higher pain and ulceration risks.
August 2024 in “IAHS Medical Journal” This study, conducted among 50 women with female-pattern hair loss, observed that 89% had deficient or insufficient vitamin D levels and also showed low ferritin levels, suggesting these deficiencies may contribute to hair loss.
May 2024 in “Journal of Pakistan Association of Dermatologists” In this randomized control trial, researchers reported that topical calcipotriol was more effective than topical tacrolimus in promoting hair growth for patients with alopecia areata over a 6-month period, with a statistically significant difference in efficacy.
This study found that an extract treatment showed similar efficacy and tolerability to calcipotriol/betamethasone ointment in reducing psoriasis severity and symptoms over 28 days in patients with mild-to-moderate plaque psoriasis.
November 2023 in “Research Square (Research Square)” This double-blinded randomized clinical trial found that combining topical vitamin D analog (calcipotriol) and intra-lesion PRP led to a greater reduction in hair loss severity in alopecia areata patients compared to either treatment alone, with significant improvements observed across all groups.
September 2023 in “Journal of the American Academy of Dermatology” This study discusses calcinosis cutis and alopecia totalis, highlighting the need for thyroid disease screening in children with alopecia areata, especially those with a history of Down syndrome or signs of potential thyroid dysfunction.
This case study presented by the researchers describes the effective use of topical calcipotriene ointment in treating a 6-year-old girl with en coup de sabre scleroderma, resulting in normalization of the sclerotic skin, hair regrowth, and improved pigmentation.
April 2023 in “Journal of Investigative Dermatology” This study suggests that the CsA-induced inactivation of the CaN/NFAT pathway may suppress TGF-β2 expression in dermal papilla cells, potentially contributing to CsA-associated hypertrichosis.
May 2020 in “JAAD case reports” This source describes a previous case report that combined anthralin and calcipotriene to treat alopecia areata, showing promising results, but highlights that further research is needed to understand the mechanisms and potential benefits of this combination therapy.
May 2020 in “International Journal of Dermatology and Venereology” This article discusses the characteristics, clinical presentation, and diagnosis of calcified epidermal cysts but reports no new clinical results.
January 2020 in “Frontiers in Medical Case Reports” This case study reported that reducing glucocorticoids resolved calcinosis cutis in a dog with hypoadrenocorticism, while demodicosis was treated with a fluralaner chewable tablet.
December 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that redhaired individuals consistently had higher calcidiol levels compared to non-redhaired subjects, suggesting a physiological adaptation for vitamin D synthesis in low UV-B conditions.
August 2019 in “International journal of dermatology and venereology” This review discusses the calcineurin/NFAT pathway's role in cutaneous squamous cell carcinoma, noting its involvement in tumor development, skin cell behavior, and the tumor microenvironment; it reports no new results.