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Glossary Botox

neurotoxin that temporarily paralyzes muscles to reduce wrinkles

Botox, also known as Botulinum Neurotoxin Type A, is a neurotoxic protein produced by the bacterium Clostridium botulinum. It is commonly used in both medical and cosmetic procedures to temporarily paralyze muscles, thereby reducing the appearance of wrinkles and treating conditions such as chronic migraines, muscle spasms, and excessive sweating.

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research Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

58 citations , February 2021 in “Toxins”

This review concluded that botulinum toxins have various potential off-label uses for dermatological conditions, but further research is needed to fully establish their efficacy and safety in these applications.

research Botulinum Toxin Off-Label Use in Dermatology: A Review

53 citations , January 2017 in “Skin appendage disorders”

This review discusses botulinum toxin's experimental off-label uses in dermatology, highlighting promising results but emphasizing the need for more clinical trials to confirm efficacy and safety.

research Cosmetic Treatment Using Botulinum Toxin in the Oral and Maxillofacial Area: A Narrative Review of Esthetic Techniques

52 citations , January 2023 in “Toxins”

This narrative review discusses expert consensus on the optimal use of botulinum toxin injections for cosmetic applications in facial and oral-maxillofacial areas across Asian and Caucasian populations, highlighting injection techniques, effective doses, historical context, and potential complications.

research Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study

50 citations , November 2010 in “Plastic and Reconstructive Surgery”

This study suggests that Botox injections may increase hair count and reduce hair loss in men with androgenetic alopecia, potentially through increased blood flow and oxygen to the scalp.

The Non-Neuronal and Nonmuscular Effects of Botulinum Toxin: An Opportunity for a Deadly Molecule to Treat Disease in the Skin and Beyond

research The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond

44 citations , October 2017 in “British Journal of Dermatology”

This review discusses the broadening scope of botulinum toxin applications beyond traditional uses, highlighting its effects on non-neuronal cells and potential in treating various dermatological conditions, without reporting new clinical findings.

research Madarosis and Facial Alopecia Presumed Secondary to Botulinum A Toxin Injections

26 citations , July 2005 in “Optometry and vision science”

This case report documents unilateral madarosis and facial alopecia as potential adverse effects of botulinum A toxin injections in a patient treated for left oromandibular dystonia.

research A pilot study to evaluate effectiveness of botulinum toxin in treatment of androgenetic alopecia in males

24 citations , January 2017 in “Journal of Cutaneous and Aesthetic Surgery”

In this pilot study, botulinum toxin was found to be a safe and effective treatment for androgenetic alopecia in most participants, though larger studies are needed to confirm these findings.

research Treatment Effects of Intradermal Botulinum Toxin Type A Injection on Alopecia Areata

24 citations , December 2010 in “Dermatologic surgery”

In this study, BTXA injections did not effectively treat recalcitrant alopecia areata or improve hair regrowth in most patients, suggesting its limitations as an alternative therapy.

research Utilities of Botulinum Toxins in Dermatology and Cosmetology

23 citations , September 2021 in “Clinical Cosmetic and Investigational Dermatology”

This review discusses the dermatological applications of botulinum toxin, including off-label uses for various skin conditions, and calls for a better understanding of underlying muscular anatomy for effective clinical practice.

research The Effects of Botulinum Toxin A on the Wound and Skin Graft Contraction

17 citations , August 2014 in “Journal of Craniofacial Surgery”

In this study on rats, botulinum toxin–A injection was reported to reduce contraction in wounds and skin grafts, with changes in inflammation and collagen arrangement also observed.

research The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

In this study, intradermal injection of botulinum toxin was associated with increased hair growth in men with androgenetic alopecia through the suppression of TGF-β1 secretion from dermal papilla cells.

research Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

15 citations , January 2020 in “BioMed Research International”

In this study of patients with androgenetic alopecia, botulinum toxin type A was found to significantly increase hair counts and improve hair density and coverage, with enhanced results observed when combined with oral finasteride, revealing a safe and effective treatment approach without adverse effects.

research Parry-Romberg Syndrome Vasculopathy and Its Treatment With Botulinum Toxin

15 citations , May 2013 in “Ophthalmic Plastic and Reconstructive Surgery”

In this case study, repetitive botulinum type A toxin injections led to almost complete resolution of severe chronic pain in a patient with Parry-Romberg syndrome.

research Is there a therapeutic effect of botulinum toxin on scalp alopecia? Physiopathology and reported cases: A systematic review of the literature

13 citations , May 2020 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

This systematic review found inconclusive evidence on the effectiveness of botulinum toxin for treating alopecia and highlighted the need for further prospective randomized controlled trials.

research A small dose of botulinum toxin A is effective for treating androgenetic alopecia in Chinese patients

12 citations , December 2018 in “Dermatologic Therapy”

Small Botox dose effectively treats hair loss in Chinese men.

research Frontal Alopecia after Repeated Botulinum Toxin Type A Injections for Forehead Wrinkles: An Underestimated Entity?

12 citations , January 2016 in “Skin appendage disorders”

This study reports that women receiving periodic injections of botulinum toxin type A for forehead wrinkles may experience frontal alopecia, with progressive hairline recession observed in the cases studied.

research Prevention of unfavourable effects of cigarette smoke on flap viability using botulinum toxin in random pattern flaps: An experimental study

12 citations , August 2015 in “Plastic Surgery”

This study found that botulinum toxin type A significantly reduced skin flap necrosis in rats exposed to cigarette smoke, suggesting it may help improve flap viability in smokers.

research Radiation-induced Alopecia Treated with Botulinum Toxin Type A Injection

10 citations , October 2014 in “Plastic & Reconstructive Surgery Global Open”

In this case study, Botulinum toxin type A injections were associated with improved hair growth and scalp condition in a patient with radiation-induced alopecia, though the mechanisms remain speculative.

Intrauterine Botulinum Toxin A Administration Promotes Endometrial Regeneration Mediated by IGFBP3-Dependent OPN Proteolytic Cleavage in Thin Endometrium

research Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

9 citations , January 2023 in “Cellular and Molecular Life Sciences”

This study found that intrauterine administration of botulinum toxin A improved endometrial environment and receptivity in a murine model of thin endometrium through mechanisms involving IGFBP3 and osteopontin.

research Lateral oblique forehead lines: redefining sleeping lines and treatment with botulinum toxin A

9 citations , June 2013 in “Journal of Cosmetic Dermatology”

The study suggests that lateral oblique forehead lines result from muscle contractions and can be effectively treated with onabotulinum toxin A, rather than being caused by sleeping position.

research The combination of platelet‐rich plasma with botulinum toxin A in the treatment of hyaluronic acid embolic cutaneous necrosis and alopecia

8 citations , March 2022 in “Dermatologic Therapy”

This article provides information on data availability but reports no new research findings.

research Aesthetic Treatment With Botulinum Toxin: Approaches Specific to Men

8 citations , October 2017 in “Dermatologic Surgery”

This review discusses male-specific techniques for botulinum toxin application to enhance aesthetic treatment outcomes in men and reports no new clinical results.

research Beauty, Biological Weapons, and Botox

7 citations , April 2002 in “Science”

This article discusses the evolving use of botulinum toxin for medical and aesthetic purposes, highlighting its potential benefits for conditions like headaches and cerebral palsy, and notes ongoing regulatory challenges.

research Multiple apocrine hidrocystomas successfully treated with botulinum toxin A

6 citations , May 2016 in “British Journal of Dermatology”

This study reports the effective use of botulinum toxin A in treating multiple facial apocrine hidrocystomas in a 29-year-old man, a case not previously documented in English-language literature.

research Off-Label Use of Botulinum Toxin in Dermatology—Current State of the Art

5 citations , May 2022 in “Molecules”

This article reviews the literature on the off-label use of botulinum toxin for dermatological conditions, highlighting its potential effectiveness in treating rosacea, anal fissures, Raynaud phenomenon, hypertrophic scars, keloids, and hidradenitis suppurativa.

research Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects

4 citations , August 2022 in “Aesthetic Surgery Journal”

This study found that one session of intradermal botulinum toxin type A injection decreased scalp sebum secretion and perception of greasiness more effectively than saline for up to 3 months.

research Is there a rationale for the use of botulinum toxin in the treatment of Androgenetic Alopecia?

4 citations , April 2021 in “Journal of Cosmetic Dermatology”

Botulinum toxin may help hair loss by increasing blood flow and reducing harmful factors.

research Botulinum toxin type A for the management of hidradenitis suppurativa.

4 citations , January 2021 in “PubMed”

This review discusses the pathogenesis and management of hidradenitis suppurativa, examining conventional treatments and exploring botulinum toxin type A as a potential therapeutic option, but it reports no new clinical results.

research Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study

3 citations , January 2022 in “Journal of Cosmetic Dermatology”

This study found that for treating androgenetic alopecia, LC hair essence serum injections provided excellent results with fewer side effects compared to botulinum toxin A, which also showed significant efficacy but with higher associated costs and more frequent side effects.

research The Effect of Botulinum Toxin on Hair Follicle Cell Regeneration Under Continuous Stress Conditions: a Pilot Animal Study

3 citations , January 2022 in “Neurotoxicity Research”

This study found that botulinum toxin type A injections in stressed mice appeared to normalize hair follicle regeneration cycles and reduced stress-related hair loss indicators.