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Glossary Bioluminescence Imaging

detects light from bioluminescent proteins to visualize biological processes

Bioluminescence Imaging (BLI) is a technique used to visualize and track biological processes in living organisms by detecting light emitted from bioluminescent proteins, such as those from fireflies. This method is particularly useful in research for monitoring gene expression, tumor growth, and the spread of infections in real-time, without the need for invasive procedures.

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research In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells

14 citations , January 2018 in “Scientific reports”

This study demonstrated that bioluminescence imaging of NG2+ cells in transgenic rats allows in vivo monitoring of hair follicle cycles to study hair growth and follicle regeneration.

research Temporal Variations of Skin Pigmentation in C57Bl/6 Mice Affect Optical Bioluminescence Quantitation

60 citations , October 2010 in “Molecular Imaging and Biology”

This study observed that skin pigmentation significantly attenuates bioluminescent signals in C57Bl/6 mice, complicating quantitative optical imaging and requiring consideration in experimental design.

research Light-Emitting Hair Follicles: Studying Skin Regeneration With In Vivo Imaging

May 2014 in “Journal of Investigative Dermatology”

This article reviews recent imaging and genetic tool advances that enable in vivo study of hair regeneration and assessment of skin parameters, but it reports no new clinical results.

research Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics

16 citations , February 2014 in “Journal of Investigative Dermatology”

This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.

research In Vivo Monitoring of Survival and Proliferation of Hair Stem Cells in a Hair Follicle Generation Animal Model

6 citations , July 2013 in “Molecular Imaging”

This study successfully used noninvasive bioluminescence imaging to monitor hair generation in vivo after transplanting hair follicle stem cells in mice.

research In vivo monitoring of survival and proliferation of hair stem cells in hair follicle regeneration animal model

May 2012 in “The Journal of Nuclear Medicine”

This study found that bioluminescence imaging can feasibly and non-invasively monitor hair follicle regeneration in mouse models by tracking transplanted hair follicle stem cells expressing a luciferase reporter gene.

research Live imaging of Smad2/3 signaling in mouse skin wound healing

12 citations , September 2007 in “Wound repair and regeneration”

This study found that in vivo bioluminescence can track Smad2/3-dependent TGF-β signaling during the wound healing process in mice, with signaling increasing after healing rather than immediately post-wounding.

research Imaging to study solid tumour origin and progression: lessons from research and clinical oncology

5 citations , March 2017 in “Immunology and Cell Biology”

This review discusses recent advances in biomedical imaging for cancer research, particularly highlighting improved imaging tools for studying solid tissue malignancies, and reports no new clinical results.

research Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury

4 citations , February 2020 in “Cell & tissue research/Cell and tissue research”

This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.

Application of Second Near Infrared Fluorescence Imaging to Trace CelTrac1000-Labeled Hair Follicle Epidermal Neural Crest Stem Cells in Repairing Rat Facial Nerve Defects

research Application of second near infrared fluorescence imaging to trace CelTrac1000-labeled hair follicle epidermal neural crest stem cells in repairing rat facial nerve defects

November 2023 in “Research Square (Research Square)”

In this study, researchers used NIR-II fluorescence imaging to track the survival and migration of EPI-NCSCs in rat models, finding that these stem cells aided in repairing facial nerve defects when applied via acellular nerve allografts.

research Engineering molecular imaging strategies for regenerative medicine

20 citations , September 2018 in “Bioengineering & Translational Medicine”

This review discusses regenerative medicine and explores the potential of molecular imaging in enhancing personalized therapies, but it reports no new research results.

research Intravital imaging of host–parasite interactions in skin and adipose tissues

28 citations , March 2019 in “Cellular Microbiology”

This review discusses the advancements enabled by intravital microscopy in understanding host-parasite interactions in living animals and reports no new clinical results.

Stem Cell Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies

research Stem Cells Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies

9 citations , March 2011 in “Current Pharmaceutical Biotechnology”

This review discusses current stem cell technologies, their potential therapeutic uses, and imaging techniques for tracking transplanted cells, without reporting new experimental results.

research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair

24 citations , May 2016 in “Stem Cell Reviews and Reports”

This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.

research Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time

5 citations , May 2023 in “Frontiers in Immunology”

This review provides an overview of how advancing imaging technologies, such as tissue clearing and intravital microscopy, are enhancing our understanding of tumor architecture and interactions between cancer cells and the tumor microenvironment, aiding both fundamental cancer research and the development of therapies.

research Dual-Reporter Gene-Based Multimodal Imaging for Tracking Mesenchymal Stem Cells in Diabetic Skin Wound Repair

August 2026 in “Stem Cell Reviews and Reports”

research Functional endoscopy techniques for tracking stem cell fate

5 citations , March 2019 in “Quantitative Imaging in Medicine and Surgery”

This review discusses recent advances in imaging techniques for monitoring stem cells in vivo and reports no new results; it suggests directions for future development in endoscopic molecular imaging tools.

research Fluorescence Microscopy—An Outline of Hardware, Biological Handling, and Fluorophore Considerations

97 citations , December 2021 in “Cells”

This review outlines key considerations for designing fluorescence microscopy experiments in cell biology, discussing the importance of hardware availability, suitability of biological models, and imaging agents to achieve high-resolution and informative images.

Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata

59 citations , October 2012 in “Pharmaceutical Research”

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

The Application of Optical Technology in the Diagnosis and Therapy of Oxidative Stress-Mediated Hepatic Ischemia-Reperfusion Injury

research The application of optical technology in the diagnosis and therapy of oxidative stress-mediated hepatic ischemia-reperfusion injury

February 2023 in “Frontiers in Bioengineering and Biotechnology”

This review discusses the potential of optical techniques for diagnosing and treating oxidative stress-related hepatic ischemia-reperfusion injury, highlighting the need for non-invasive diagnostic methods and the anti-oxidative potential of optical therapies; it reports no new clinical results.

research Regeneration Genetics

39 citations , August 2017 in “Annual Review of Genetics”

This review discusses recent genetic approaches to understanding tissue regeneration mechanisms in vertebrates and reports no new results; it highlights objectives in identifying cellular and molecular factors involved.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.

research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts

2 citations , October 2015 in “Human Gene Therapy”

The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.

Adipose-Derived Stem Cell Exosomes Promote Critical-Sized Bone Defect Repair by Enhancing the Homing of Bone Marrow Mesenchymal Stem Cells

research Adipose-derived stem cell exosomes promote critical-sized bone defect repair by enhancing the homing of bone marrow mesenchymal stem cells

January 2026

This study observed that exosomes derived from adipose-derived stem cells significantly enhanced bone marrow mesenchymal stem cell migration and osteogenesis, leading to improved bone regeneration in a rat model of calvarial defects.

research The E6/E7 oncogenes of human papilloma virus and estradiol regulate hedgehog signaling activity in a murine model of cervical cancer

9 citations , May 2019 in “Experimental Cell Research”

This study found that Hedgehog signaling likely contributes to cervical carcinogenesis, and while itraconazole reduced growth in mice, it did so through pathways other than inhibiting Hedgehog signaling.

research Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid

23 citations , January 2014 in “Molecular Therapy”

This study found that topically delivering KGF-1 DNA plasmid increased epithelial thickness and skin strength, suggesting potential benefits for strengthening compromised skin.

research Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

520 citations , January 2017 in “AIMS biophysics”

This review discusses the effects of photobiomodulation, particularly its potential to reduce inflammation in various conditions, but it does not report new clinical findings.

research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.

research Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies

104 citations , January 2016 in “Food & Function”

This review found that olive oil phenols may have anti-cancer properties in animal models and some human studies, but further research is needed to confirm these effects in humans.