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Glossary Biologics

medications derived from living organisms to treat various diseases

Biologics, also known as biological drugs or biopharmaceuticals, are a category of medications derived from living organisms, such as cells, tissues, or proteins. Unlike traditional chemical drugs, biologics are typically large, complex molecules that target specific components of the immune system or cellular processes, making them effective for treating conditions like autoimmune diseases, cancers, and certain types of alopecia.

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research Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis

20 citations , January 2024 in “Journal of the European Academy of Dermatology and Venereology”

This study conducted a meta-analysis and found that among therapies for alopecia areata, baricitinib_4 mg was most likely to be effective, followed by ritlecitinib and ivarmacitinib, while other treatments like dupilumab and secukinumab were less effective.

Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors

12 citations , December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

This review suggests that oral Janus kinase inhibitors are a promising treatment for alopecia areata in adults, showing significant hair regrowth with fewer side effects than conventional treatments, while PDE-4 inhibitors and biologics show limited efficacy.

research Biologics and Small Molecule Targeted Therapies for Pediatric Alopecia Areata, Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa in the US: A Narrative Review

8 citations , July 2024 in “Children”

This study discusses how emerging biologics and small molecule therapies could enhance disease management and pediatric health outcomes for chronic skin conditions, suggesting their potential inclusion in treatment guidelines pending ongoing clinical trial successes.

Cutaneous Drug Eruptions Associated with the Use of Biologics and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

research Cutaneous Drug Eruptions Associated with the Use of Biologies and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

4 citations , January 2012 in “Chemical Immunology”

This paper discusses the challenges of diagnosing drug eruptions, emphasizing the nonspecific patterns and unclear pathomechanisms, and calls for further research using new biologic drugs to understand these reactions better.

research Biologics in the management of childhood atopic dermatitis

4 citations , January 2023 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study reported that dupilumab, an FDA-approved biologic, is a safe and effective first-line systemic treatment for children with moderate-to-severe atopic dermatitis, showing sustained skin improvement and itch reduction, with injection site reactions and conjunctivitis as potential side effects.

Off-Label Use of Biologics and Janus Kinase Inhibitors for Scarring Alopecias: A Narrative Review

research Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review

3 citations , June 2025 in “Archives of Dermatological Research”

In this review, researchers found that TNF-α, IL-17, and JAK inhibitors show the most promise for stabilizing and resolving scarring alopecias, with IL-23 and Interferon Alpha Receptor 1 inhibitors also providing some benefits in managing these hair loss conditions.

research Change in the Usage of Complementary and Alternative Medicine in the Era of Biologics Among Korean Patients With Psoriasis

3 citations , January 2023 in “Journal of Korean Medical Science”

In this study, researchers found that complementary and alternative medicine remains widely used by Korean patients with psoriasis despite advances in biologic treatments, highlighting the need for better education on conventional therapies.

research Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events

2 citations , April 2025 in “Biologics”

This study reviewed clinical trials and reports on cytokine-targeting biologics for alopecia areata, finding Dupilumab and Ustekinumab showed strong efficacy, while other biologics had limited success or worsened the condition. Further research is needed to optimize biologic therapies for AA.

research Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review

1 citations , December 2024 in “Indian Dermatology Online Journal”

This research notes that biologics and small molecules are effective for treating nail psoriasis and alopecia areata, albeit with precautions for adverse events, but no clinical trials have been published for their use in treating nail lichen planus and atopic dermatitis.

Ixekizumab Improves Physical Function, Quality of Life, and Work Productivity in Biologic Disease-Modifying Antirheumatic Drug-Naive Patients with Active Psoriatic Arthritis

research Ixekizumab improves physical function, quality of life, and work productivity in biologic disease-modifying antirheumatic drug-naive patients with active psoriatic arthritis

1 citations , April 2016 in “Journal of The American Academy of Dermatology”

Ixekizumab helps improve life quality, physical ability, and work performance in patients with psoriatic arthritis who haven't used biologic drugs before.

research A Commentary on the Need for Minimum Information for Studies Evaluating Biologics in Plastic Surgery

April 2026 in “Journal of Plastic Reconstructive & Aesthetic Surgery”

This article reviews the use of biologics like platelet-rich plasma and mesenchymal stem cells in plastic surgery but highlights a lack of standardization in reporting platelet concentrations, which limits the systematic evaluation of their efficacy and application.

research Paradoxical reactions in the era of modern biological therapy of psoriasis — a comprehensive analysis of pathomechanisms and clinical guidelines

January 2026 in “Forum Dermatologicum”

This study systematically reviewed literature on paradoxical reactions during biologic treatments for psoriasis, identifying immune dysregulation mechanisms and diverse clinical manifestations, highlighting that mild cases often respond well to topical treatments, while severe cases may require switching to different IL-23 inhibitors.

research Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review

December 2024 in “International Journal of Dermatology”

JAK inhibitors may help treat both alopecia areata and vitiligo, but more research is needed.

research 41261 Identification of Demographic and Clinical Features Associated with Multi-Biologic Failure in the CorEvitas Psoriasis Registry

September 2023 in “Journal of the American Academy of Dermatology”

Certain factors like being female, having high cholesterol, using Medicaid, and previous non-biologic treatments increase the risk of multiple biologic failures in psoriasis patients.

research PSS33 REAL-LIFE DOSING OF BIOLOGICS IN PLAQUE PSORIASIS—A GERMAN SURVEY

November 2010 in “Value in Health”

Real-life dosing of biologics for plaque psoriasis often deviates from recommended guidelines, especially for high-need patients.

research A Layered Framework for Biological Aesthetics: A Narrative Review of Regenerative Medicine in Cosmetic Science

September 2026 in “Cureus”

In this narrative review, the authors discuss regenerative substances like platelet-rich fibrin and mesenchymal stem cells in biological aesthetics, noting that while these methods show promise for regeneration, their safety, effectiveness, and durability remain uncertain due to limited and heterogeneous evidence.

research Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review

April 2026 in “Dermatology and Therapy”

This study reviews the efficacy and safety of advanced therapies like TNFα inhibitors and IL-17/IL-23 inhibitors for dissecting cellulitis of the scalp, finding TNFα inhibitors particularly effective for severe or refractory cases, although prospective validation is needed for early intervention benefits.

research Biologically Driven Innovations in Aesthetic Surgery: Advances in Regenerative and Cellular Therapies

November 2025 in “IECCMEXICO”

This review found that adipose-derived stem cells and stromal vascular fraction have robust clinical benefits in aesthetic surgery, particularly in facial rejuvenation, scar treatment, and volumetric restoration, with favorable safety profiles.

Humoral Immune Response to COVID-19 Vaccination in Psoriasis Patients on Biologic Therapy Is Impaired Compared to Healthy Controls

research 224 Humoral immune response to COVID-19 vaccination in psoriasis patients on biologic therapy is impaired compared to healthy controls

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that psoriasis patients on biologic therapy had significantly lower anti-COVID19 IgG antibody levels after vaccination compared to healthy individuals not on biologic treatment.

research Biologic: A Double Edged Sword - A Case of Etanercept Induced Alopecia Areata in a Patient with Psoriasis Vulgaris

January 2018 in “SOJ microbiology & infectious diseases”

This review outlines the changing landscape of psoriasis vulgaris treatment with biologics, which offer benefits but also have increasingly recognized adverse effects, without presenting new clinical results.

research scMC learns biological variation through the alignment of multiple single-cell genomics datasets

822 citations , January 2021 in “Genome biology”

This study presents a new method called scMC that effectively distinguishes biological from technical variation in single-cell genomics datasets, demonstrating its ability to accurately align and detect biological signals across various experiments.

research Biological Function of Long Non-coding RNA (LncRNA) Xist

247 citations , June 2021 in “Frontiers in Cell and Developmental Biology”

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

research Biological aspects in controlling angiogenesis: current progress

85 citations , June 2022 in “Cellular and Molecular Life Sciences”

research An Unusual Form of Vitamin D-Dependent Rickets in a Child: Alopecia and Marked End-Organ Hyposensitivity to Biologically Active Vitamin D

82 citations , October 1980 in “The Journal of Clinical Endocrinology & Metabolism”

This case study describes a child with an unusual form of vitamin D-dependent rickets, characterized by alopecia and a deficient response to active vitamin D.

research BIOLOGICAL ACTIVITY OF ANTIANDROGENS

51 citations , June 1970 in “British journal of dermatology/British journal of dermatology, Supplement”

This review discusses the biology of antiandrogens and highlights available bioassay models to predict their therapeutic effects on human skin, reporting no new clinical results.

research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

43 citations , January 2016 in “Oxidative medicine and cellular longevity”

This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.

research Biological observations from feeding heated corn oil and heated peanut oil to rats

36 citations , July 1987 in “Journal of toxicology and environmental health”

This study found that rats fed diets with heated corn or peanut oil showed signs of toxicity, including liver and kidney weight increases, diarrhea, and ceased spermatogenesis, compared to those consuming fresh oils.

research Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review

28 citations , December 2005 in “Oncogene”

research Biological characterization of cultured dermal papilla cells and hair follicle regeneration in vitro and in vivo

24 citations , February 2006 in “Chinese Medical Journal”

This study found that dermal papilla cells cultured in vitro can promote hair follicle regeneration and maintain hair growth, with stronger ET-1 and SCF expression enhancing this regenerative ability.

research Biological Features Implies Potential Use of Autologous Adipose-Derived Stem/Progenitor Cells in Wound Repair and Regenerations for the Patients with Lipodystrophy

23 citations , November 2019 in “International Journal of Molecular Sciences”

This study found that adipose-derived stem cells from HIV-infected patients with lipodystrophy associated with HAART demonstrated similar growth and differentiation potential as those from HIV-uninfected patients, suggesting potential for autologous regenerative therapy.