1 citations
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December 2022 in “Skin Research and Technology” This article provides guidelines and indices for a three-point cantilever bending test to measure mechanical properties of hair treated with both conventional and naturally-derived styling polymers, reporting no new experimental results.
119 citations
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November 2009 in “Human Reproduction” This study found that women with polycystic ovary syndrome have a higher prevalence of non-alcoholic fatty liver disease and increased androgen bioavailability may be involved alongside metabolic factors.
114 citations
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March 2018 in “PLOS Medicine” This study found that women with polycystic ovary syndrome have higher rates of nonalcoholic fatty liver disease, with androgen excess contributing to the risk.
84 citations
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September 2008 in “Developmental biology” This study found that cellular retinoic acid-binding proteins and fatty acid-binding proteins are dynamically expressed in skin development and respond differently to retinoic acid, β-catenin, and Notch signaling.
35 citations
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December 2009 in “Human reproduction” This study found that metformin treatment during pregnancy in women with PCOS was associated with higher SHBG levels in newborns, but did not affect androgen or estrogen levels at birth.
18 citations
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June 2017 in “Proceedings of the National Academy of Sciences of the United States of America” In this mouse study, hair growth defects associated with the Gk5 null allele were partially alleviated by simvastatin treatment, suggesting GK5 plays a key role in skin-specific cholesterol regulation.
18 citations
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May 2014 in “Menopause” This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.
13 citations
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December 2020 in “BMJ Open Diabetes Research & Care” This study found that while intensive lifestyle interventions were associated with favorable changes in SHBG levels due to reduced adiposity, these changes did not consistently predict diabetes risk reduction.
13 citations
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June 2018 in “Journal of Womens Health” This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.
11 citations
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December 2010 in “The Journal of Urology” This study found that combining oral testosterone with dutasteride increased testosterone bioavailability in hypogonadal men while suppressing dihydrotestosterone levels over a 28-day period.
7 citations
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August 2020 in “Animal biotechnology” This study found that lncRNA-599547 positively regulates the expression of the Wnt10b gene by interacting with miR-15b-5p, enhancing the inductive property of dermal papilla cells in cashmere goats.
7 citations
,
May 2012 in “International Journal of Andrology” This study found that an oral testosterone formulation normalized serum testosterone levels and significantly reduced SHBG in men with experimentally induced hypogonadism after nine days of treatment, suggesting potential efficacy for testosterone deficiency.
7 citations
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October 2017 in “The Prostate” This study found that male pattern baldness may serve as a clinical marker for circulating sex hormone levels in men with localized prostate cancer, while chest hair density showed no significant hormone association.
5 citations
,
September 2010 in “Cancer Prevention Research” This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.
4 citations
,
June 2022 in “Journal of cleaner production” This study found that a new eco-friendly hair crosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.
3 citations
,
November 2017 in “International Journal of Cosmetic Science” This study found that increasing the pH from 2.0 to 6.0 enhanced the binding of cationic solutes to hair keratin, driven primarily by hydrophobic and electrostatic interactions.
2 citations
,
April 2018 in “Journal of Investigative Dermatology” This study suggests that frontal fibrosing alopecia is a highly inflammatory disease involving TH1 and JAK-STAT pathways, without reduced hair keratins, highlighting JAK-STAT signaling as a potential therapeutic target.
1 citations
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October 2023 in “Frontiers in endocrinology” This study found that sex hormone-binding globulin promotes facial aging, while sex steroid hormones such as testosterone and estradiol inhibit it, with growth hormone levels showing no significant effect.
1 citations
,
March 2021 in “Journal of Experimental Biology and Agricultural Sciences” This study observed that consuming flaxseeds significantly reduced serum free testosterone and improved insulin levels among young women with PCOS, suggesting a promising alternative to conventional treatments.
1 citations
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January 2015 in “Hair therapy & transplantation” This investigation found that certain supplements, particularly whey protein isolate, growth hormones, and anabolic steroids, can negatively impact hair loss by affecting biochemical pathways.
October 2025 in “Clinical Cosmetic and Investigational Dermatology” This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.
May 2025 in “Anatolian journal of obstetrics and gynecology research.” This source highlights the essential role of androgens in women's health, noting their impact on various body systems and the critical need for more research on androgen therapies regarding side effects, patient selection, and laboratory standardization.
October 2023 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that in women with PCOS, insulin resistance is closely associated with hyperandrogenism, indicating it may independently predict increased androgen levels.
This study found that metabolic syndrome is more common in individuals with androgenic alopecia compared to those without, and that free androgen index could help identify those with the syndrome.
May 2019 in “The Journal of Sexual Medicine” This study found no baseline factors that predicted flibanserin efficacy for HSDD, though low testosterone or use of hormonal contraceptives were associated with reduced efficacy.
January 2025 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that insulin resistance is common among Pakistani women with PCOS and is independently associated with increased hyperandrogenism, as indicated by correlations with testosterone levels and other androgenic measures.
May 2026 in “Journal of Assisted Reproduction and Genetics” In this study, researchers developed and tested a novel peptide, AMHR2BP, which mimics the function of Anti-Müllerian hormone to protect ovarian follicles in mice, showing promise for preserving ovarian health during chemotherapy without causing toxicity.
23 citations
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March 2014 in “International Journal of Molecular Sciences” The study observed that testosterone reduced knee range of motion in ovariectomized female rats, potentially by downregulating specific relaxin receptor isoforms, with its effects mediated via dihydro-testosterone.
4 citations
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January 2023 in “Journal of Clinical Investigation” This study identified a recurrent mutation in the endothelin receptor type A associated with mandibulofacial dysostosis with alopecia, and proposed a mechanism involving increased ligand affinity due to structural changes.
2 citations
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April 2023 in “Pharmaceuticals” This study evaluated the anti-alopecia activity of compounds from Merremia peltata leaf in rabbits and found that scopolin has a promising effect on hair growth and androgen receptor affinity, potentially offering a new treatment option for alopecia.