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This study found that the alkaloids cepharanthine and berbamine bind to SK2 and SK3 channel subtypes with affinities that match their concentrations active against various diseases, prompting further investigation into SK channels' role in their therapeutic effects.

In this study, a novel electrospun dressing patch made with radially oriented PHBV nanofibers and loaded with berberine was shown to significantly accelerate diabetic wound healing in mice, achieving 100% wound closure in 18 days while also demonstrating improved mechanical and anti-inflammatory properties.

This animal study found that berberine may alleviate benign prostatic hyperplasia by reducing inflammation and oxidative stress through inhibition of the NF-κB signaling pathway.

This review article summarized the design, synthesis, and application of innovative delivery systems for berberine, highlighting their potential to enhance wound healing through improved bioactivity and bioavailability, particularly in challenging conditions like diabetic and infected wounds.

In this study, researchers developed and optimized a smartlipid nanocarrier gel formulation of berberine that significantly reduced hair loss and promoted faster hair regrowth in a testosterone-induced hair loss model, showing potential as an effective treatment for androgenetic alopecia.

In this study, gelatin methacrylate hydrogel dressings co-loaded with resveratrol, 18-β-glycyrrhetinic acid, and berberine showed enhanced capabilities in wound closure, infection clearance, and skin structure regeneration in mice with infected wounds compared to dressings with single agents.

This study identified hypericin and berberine as compounds that can support hair growth by enhancing oxytocin receptor expression and acting as an oxytocin receptor agonist, respectively, potentially serving as practical alternatives to oxytocin for treating hair-loss diseases.

This study suggests that berberine may offer multiple benefits for women with polycystic ovary syndrome by improving metabolic and hormonal profiles, though further research is needed on its long-term effects on reproductive outcomes.

This study conducted an in silico evaluation and found that berberine displayed better binding interactions with the 5α-reductase enzyme and TGF-β2 compared to minoxidil, suggesting its potential as a therapeutic agent for androgenetic alopecia.

This study found that berberine supplementation improved gut microbiota composition and reduced obesity-related hepatic inflammation and oxidative stress in genetically obese mice.

This study reported that a novel nanomedicine combining berberine and sinapic acid significantly inhibited the growth of mouse mammary carcinoma cells and demonstrated an anti-tumor effect in vivo, without significant systemic toxicity after 28 days, suggesting a promising, low-toxicity therapeutic strategy for breast cancer.

In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.

This study found that bisbenzylisoquinoline alkaloids from Stephania cepharantha Hayata stimulated growth in cultured murine hair cells but not in keratinocytes or fibroblasts.

This review explores lifestyle modifications for women with polycystic ovary syndrome, discussing dietary, physical, and supplementation strategies, but reports no new clinical results.

This review discusses the disruption of hormonal and metabolic rhythms in polycystic ovary syndrome and explores potential drug targets to address its molecular causes, without providing new clinical results.

This study presents a composite hydrogel dressing with berberine-loaded silk fibroin microspheres and Calotropis gigantea fibers that demonstrates effective antibacterial properties, enhanced mechanical strength, and promotes wound healing.

In this review, the authors emphasize that dietary changes, nutraceuticals, and herbal remedies like curcumin, berberine, and cinnamon can potentially improve metabolic and reproductive health, making these interventions promising for managing PCOS alongside traditional pharmaceutical treatments.

This study presents a novel composite hydrogel dressing with berberine-loaded silk fibroin microspheres and Calotropis gigantea fibers, demonstrating enhanced antibacterial activity, mechanical strength, and wound healing capabilities in treating chronic and infected wounds.

This study reviews 10 herbal supplements, including Berberine and Cinnamon, as alternative treatments for PCOS, noting they are more accessible and affordable than conventional medications, especially in low-resource settings, though further clinical research is needed.

A balanced diet and healthy lifestyle help manage PCOS symptoms.

This chapter reviews nutritional strategies for managing polycystic ovary syndrome, emphasizing dietary adjustments and lifestyle changes, but it does not report new clinical findings.

This review reported that various herbs including cinnamon, fenugreek, and turmeric may effectively treat polycystic ovarian disorder with minimal side effects, suggesting potential for herbal therapies to target the disorder's root causes and improve overall health.

This study explores potential treatments for post COVID-19 complications using natural substances through molecular docking, but reports no new clinical results and existing treatments remain limited to prophylaxis and therapeutics.

This study found that bis-benzylisoquinoline and Amaryllidaceae alkaloids, especially aromoline, show potential as antiviral agents, suggesting they could serve as foundations for developing new treatments against coronaviruses by enhancing the understanding of their structure-activity relationships.

This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.

This review discusses the use of Traditional Chinese Medicine in burn treatment and details various herbs with potential therapeutic benefits, but reports no new clinical findings.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

The authors concluded that specific comorbidities and complications increase the risk of severe COVID-19 and impede patient recovery, making them critical factors to control in order to lessen the disease's adverse effects.

Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.