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270-300 / 1000+ resultsresearch COVID‐19 and cutaneous manifestations: A review of the published literature
This review discusses various skin manifestations associated with COVID-19, emphasizing their potential role in early diagnosis and management of the infection, but reports no new clinical findings.
research Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems
This article reviews various strategies, primarily developed by the Turin University Pharmaceutical Technology group, for increasing entrapment efficiency of hydrophilic molecules in nanoparticulate systems and reports no clinical results.
research Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression
This study found that nuclear beta-catenin, LEF1, and PHLDA1 expression was conserved in matrical tumors, suggesting a shared tumorigenesis process involving Wnt pathway activation.
research Goat Genomic Resources: The Search for Genes Associated with Its Economic Traits
This review examines over 271 candidate genes associated with economic traits in goats, highlighting their potential use in genetic markers and future breeding programs, and reports no new experimental results.
research FGFR2 is associated with hair thickness in Asian populations
This study found that an SNP in the FGFR2 gene, rs4752566, was significantly associated with hair thickness in Asian populations, suggesting an effect on hair morphology through altered FGFR2 expression levels.
research The developmental basis of fingerprint pattern formation and variation
In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
research Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
research Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss
This study found that long-term flutamide treatment reduced hair loss in women with female pattern hair loss, but liver-related dropouts were minimized at a very low dose of 62.5 mg/day.
research Bioactive metabolites of Ganoderma lucidum: Factors, mechanism and broad spectrum therapeutic potential
This review discusses the therapeutic potential of Ganoderma lucidum's secondary metabolites, noting their diverse health benefits, such as anticancer and antioxidant effects, without presenting new experimental results.
research Rare and common genetic determinants of metabolic individuality and their effects on human health
This study identified thousands of variant-metabolite associations in the human plasma metabolome, offering insights into the genetic bases of metabolism and potential adverse drug effects.
research Natural products reverse cancer multidrug resistance
This review highlights the potential of natural product-derived compounds, such as flavonoids and alkaloids, to reverse multidrug resistance in tumors, emphasizing their role in regulating signaling pathways, proteins, and genes related to MDR, and aims to guide future research efforts in this area.
research Prescribing testosterone and DHEA: The role of androgens in women
This review examines the roles of androgens in women's health and provides recommendations for androgen therapy but reports no new results.
research Acute generalized exanthematous pustulosis induced by hydroxychloroquine prescribed for COVID-19
This case study highlights that even short-term use of hydroxychloroquine for COVID-19 can potentially lead to acute generalized exanthematous pustulosis as an adverse effect.
research Murine Cytomegalovirus is Not Associated With Alopecia Areata in C3H/HeJ Mice
Murine cytomegalovirus does not cause alopecia areata in these mice.
research Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study
This study found that a 12-week supplementation with a combination of insulin sensitizing agents, antioxidants, and vitamins significantly improved menstrual cyclicity, acne, and hirsutism in women with PCOS, with additional weight loss benefits in obese subjects.
research [Prevalence of cutaneous lesions in Freixo de Espada à Cinta].
In this study, the researchers reported a high prevalence of specific cutaneous lesions in the Freixo de Espada à Cinta population, with significant associations between demographic factors and lesion types.
research Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours
This phase I study determined that a combination of oral SU-014813 and docetaxel is a feasible treatment with a manageable safety profile and potential anti-tumor activity, particularly noted in melanoma and GIST patients.
research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
This study found that GI198745 acts as a time-dependent inhibitor of rat 5α-reductase type 2 but a rapid-equilibrium inhibitor of type 1, potentially making it more effective than finasteride in preventing rat prostate growth.
research Influence of Homogenization of Fat on Haircoat of Dairy Calves
In this study, calves fed skim milk and soybean oil experienced hair loss over the perineal region, which regrew once they began consuming hay or grain, despite continuing the same diet.
research The role of ultrasound and Doppler analysis in the diagnosis of polycystic ovary syndrome
This review discusses the complexities of diagnosing polycystic ovary syndrome and reports no new results; the authors suggest a thorough and careful diagnostic approach to avoid misdiagnosis and unnecessary tests.
research Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones
This review discusses the role of sex hormones in COVID-19 severity and reports no new clinical results; the authors suggest further research for gender-based personalized treatment options.
research The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin‐1 (PN‐1) inhibition
This study found that the catalytically inactive serine protease CAP1/Prss8 can still induce skin disorders in mice and is subject to inhibition by nexin-1, independent of its catalytic activity.
research Medicinal Uses of L-Lysine: Past and Future
This review discusses the clinical significance of L-Lysine in treating various conditions and reports mixed findings on its effectiveness against herpes simplex virus infections, with no new experimental results presented.
research Heat‐damaged evaluation of virgin hair
This study found that thermal hair-straightening devices significantly damaged the cuticle and cortex of virgin Asian and Caucasian hair, with Asian hair experiencing more protein loss than Caucasian hair.
research Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal
This study found that acne prevalence among adults in Greater Porto's primary healthcare centers was 61.5%, with only 25% of those with acne seeking treatment.
research The relationship among androgens, insulin resistanceand ghrelin polymorphisms in post-adolescent malepatients with severe acne vulgaris
This study suggests that the gene rs27647 polymorphism may play a role in the pathogenesis of severe acne vulgaris in post-adolescent male patients.
research Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible
This case report presents two instances where typically irreversible lichen planopilaris and frontal fibrosing alopecia showed signs of hair regrowth and symptom improvement following specific treatments.
research A study of serial vertical sectioning of scalp biopsies to increase the histological diagnostic yield in alopecias
This study found that serial vertical sectioning of scalp biopsies significantly increases the histological diagnostic yield for alopecias.
research Hair sampling for cortisol analysis with mother-toddler dyads living in low-income homes
This study found that sampling hair for cortisol analysis in mother-toddler dyads living in low-income U.S. homes is feasible, with 66% of approached dyads participating.