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Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

CD4+ skin cells may be precursors to basal cell carcinoma.

Skin cancer in sun-exposed areas is more likely to come back.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Skin problems are common after stem cell transplants, and early treatment by dermatologists can improve patient outcomes.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

GLI1 might protect against the start of skin cancer and is not linked to cancer severity.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.

Certain spices may help prevent and treat skin cancer, but more human trials are needed.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

The local environment is crucial for cell development in the tongue.

Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.