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The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

The research shows that skin cancer likely originates from hair follicles and that certain cell populations expand to promote skin cancer growth.

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

Understanding where cancer cells come from helps create better prevention and treatment methods.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Dermoscopy is an effective tool for accurately detecting skin cancers.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Men are more likely to have larger basal cell carcinomas and squamous cell carcinomas, while women have more superficial basal cell carcinomas and tumors on their legs and central face.

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

Targeting the Smoothened receptor shows promise for treating certain cancers.

Key genes linked to hair growth and cancer were identified in hairless mice.

Arsenic exposure from contaminated water severely damages the skin, causing hair loss, pigmentation changes, irritation, and can lead to skin cancer.

Live imaging has advanced our understanding of stem cell behavior and raised new research questions.

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.

People with denser forearm hair have a higher risk of certain skin cancers.

Some skin tumors may start from hair follicle stem cells.

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Most people with basal cell carcinoma on their head or neck were 60-70 years old, and it often came back even after being fully removed, especially in certain areas and types.

The treatment was ineffective in humans.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

Inactive hair follicle stem cells help prevent skin cancer.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.