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New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

Most people with basal cell carcinoma on their head or neck were 60-70 years old, and it often came back even after being fully removed, especially in certain areas and types.

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

Vismodegib is effective for basal cell carcinoma but has severe side effects.

The research suggests new treatments for skin cancer could target specific cell growth pathways.

The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.

The antibody created from BCC tissues reacts similarly to both BCC and hair follicles, suggesting BCC may come from hair follicle cells.

The treatment was ineffective in humans.

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

Understanding and managing side effects of hedgehog pathway inhibitors can improve treatment for advanced basal cell carcinoma.

Activating Notch signaling can kill basal cell carcinoma cells.

A man with myotonic dystrophy type 1 had 28 skin cancers, suggesting a link between the disease and skin cancer, emphasizing the need for sun protection and regular skin checks.

A rare type of skin cancer on the scalp can be mistaken for hair loss, causing delayed diagnosis and severe damage.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Inactive hair follicle stem cells help prevent skin cancer.

TAF4 is important for skin cell growth and helps prevent skin cancer in mice.

A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.

Mohs micrographic surgery is effective for early-stage non-melanoma skin cancers on the lips, with basal cell carcinoma more common on the upper cutaneous lip and squamous cell carcinoma more common on the lower vermilion lip.

Mutations in the SHH pathway in certain skin cells can cause skin tumors and abnormal hair growth.

The exact identity of skin stem cells and how skin cells differentiate is not fully known.

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

The author now believes tricholemmal carcinoma is a rare type of infundibular squamous cell carcinoma and more research is needed on these tumors.

In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.