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    Glossary Barrier Function

    skin's defense against environmental threats and moisture loss

    The barrier function refers to the skin's ability to act as a protective shield against environmental aggressors, such as pathogens, chemicals, and physical injuries. It involves the outermost layer of the skin, known as the stratum corneum, which maintains hydration and prevents the entry of harmful substances. This function is crucial for overall skin health and integrity, and its impairment can lead to conditions like eczema and increased susceptibility to infections.

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    Research 30 of 1000+

    1. Lipid loses and barrier function modifications of the brown‐to‐white hair transition Skin research and technology · 2019 · 12 citations
    2. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    3. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    4. The Role of PGC-1α in Aging Skin Barrier Function Cells · 2024 · 8 citations
    5. 371 Hair follicles are critical modulators of skin barrier function Journal of Investigative Dermatology · 2024
    6. Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions Biological Chemistry · 2008 · 84 citations
    7. Hair follicles modulate skin barrier function Cell Reports · 2024 · 9 citations
    8. Dietary sodium hyaluronate and eggshell membrane improve skin barrier function and coat health in Ragdoll cats Frontiers in Veterinary Science · 2026
    9. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011 · 22 citations
    10. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss Scientific Reports · 2017 · 19 citations
    11. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    12. Caffeine improves barrier function in male skin International Journal of Cosmetic Science · 2006 · 33 citations
    13. The acyl-CoA binding protein is required for normal epidermal barrier function in mice Journal of Lipid Research · 2012 · 31 citations
    14. Acyl-CoA binding protein and epidermal barrier function Biochimica and biophysica acta. Molecular and cell biology of lipids · 2014 · 15 citations
    15. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    16. 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响(The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne) 中医药研究与应用(Research and application of traditional Chinese medicine) · 2025
    17. 415 Targeting inflammation and specialized pro-resolving mediators to reinforce barrier function and scalp homeostasis. Journal of Investigative Dermatology · 2022
    18. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    19. Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin Frontiers in Medicine · 2024 · 8 citations
    20. The stratum corneum barrier: impaired function in relation to associated lipids and proteins Tissue Barriers · 2024 · 7 citations
    21. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    22. Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling Molecules · 2023 · 2 citations
    23. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations
    24. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    25. 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function Journal of Investigative Dermatology · 2018
    26. Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review Health science reports · 2023
    27. 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions Journal of Investigative Dermatology · 2017
    28. Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity EMBO Molecular Medicine · 2024
    29. 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function 2018
    30. 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function Journal of Investigative Dermatology · 2017