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The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

FoxN1 overexpression in young mice harms immune cell and skin development.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

In June 2019, the stem cell research field saw major progress, including new clinical trials, FDA approvals, and industry collaborations.

Newborn screening and gene therapy are expected to improve outcomes for Omenn syndrome patients.

M-CSF-stimulated myeloid cells can cause alopecia areata in mice.

Skin lymphoproliferative disorders are hard to diagnose and often linked to systemic diseases, but most have a good prognosis with accurate diagnosis.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

A boy with severe immune deficiency and Epstein-Barr virus died from high-grade B-cell lymphoma.