January 2024 in “Archives of pathology & laboratory medicine” This study observed that adipose tissue infiltration and ESGC displacement in scalp biopsies were more frequently found in frontal fibrosing alopecia and may play a role in the development of scarring alopecia.
December 2023 in “International Journal of Medical Arts” In this study, researchers observed significant morphological and histological differences in transplanted hair follicles compared to native donor follicles post-FUE hair transplantation for androgenetic alopecia, highlighting substantial variations in sebaceous gland and root sheath degeneration at the recipient site.
July 2023 in “Journal of personalized medicine” This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.
February 2023 in “Mağallaẗ Tikrīt li-l-ʻulūm al-ṣirfaẗ/Tikrit journal of pure science” In this study, the researchers reported the detailed anatomical structure of horse skin, including the composition and organization of the epidermis, dermis, and associated glands and follicles.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.
May 2022 in “Journal of Education, Health and Sport” This review discusses the associations between dermatological disorders and increased cardiovascular risk, emphasizing that skin conditions with chronic inflammation may elevate the likelihood of cardiovascular diseases.
January 2022 in “Clinical Cases in Dermatology” This article describes pilar cysts, common dermal cysts often seen in young women, which typically require surgical removal.
April 2021 in “Indian Journal of Animal Research” This study examined the age-related changes in the dermal structure of goat skin, providing baseline data on its histomorphology, histochemistry, and histoenzymology.
February 2020 in “Journal of Physics Conference Series” This study found that laser hair removal is optimal for light to moderate skin tones using 10-15 J/cm² at 755 nm and for dark skin with 4.5-10 J/cm² at 755-1064 nm.
January 2020 in “Journal of Entomology and Zoology Studies” This study found that canine hair follicle stem cells are located in the isthmus/bulge region of the hair follicle, surrounded by telocytes.
January 2019 in “Journal of Entomology and Zoology Studies” This study observed that in Assam Hill Goats, the primary hair follicles had larger diameters and more structural associations compared to secondary follicles, especially in ruminant-age groups.
April 2016 in “British Journal of Dermatology” Eyelashes are important for looks and eye protection, and more people are treating sparse eyelashes; more research is needed to understand eyelash biology and improve treatments.
January 2015 in “Faculty of 1000 Research Ltd” Androgenetic alopecia may be irreversible due to the detachment of a muscle from hair follicles.
June 2014 in “British Journal of Dermatology” Eczema patients have a lower skin lipid to protein ratio, older and longer-staying hospital patients are more likely to get pressure ulcers, hair loss in AGA is linked to muscle degeneration, vitamin D deficiency is common in alopecia areata and linked to its severity, standard liver tests don't effectively detect fibrosis in psoriasis patients on methotrexate, and bullous pemphigoid patients have a higher death risk but combination therapy may reduce it.
January 2014 in “Reactions Weekly” A woman experienced unusual hair loss and skin reactions after taking phenobarbital, but her hair grew back after treatment.
In this study, researchers established a mouse model for single follicular unit transplantation and reported successful integration and piloerection of transplanted hair follicles with surrounding host tissues.
This study presents a new model for the progression of androgenetic alopecia, suggesting that the loss of attachment between the bulge's stem cells and the arrector pili muscle may contribute to irreversible hair miniaturization.
May 2015 in “Hair transplant forum international” This review discusses androgenetic alopecia and reports no clinical findings; the authors highlight a need for further research.
September 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Scientists successfully created fully functional hair follicles using bioengineering methods and stem cells.
263 citations
,
February 2013 in “Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology” This review discusses nanoparticle-based topical delivery systems for treating skin diseases and presents no new clinical findings; it emphasizes natural polymer-based nanoparticles and future applications like targeted drug delivery.
144 citations
,
September 2012 in “Genes & development” This study found that aging in the epidermis disrupts cytokine balance and stem cell function, which may contribute to broader tumor-suppressive mechanisms.
130 citations
,
January 1994 in “Differentiation” In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
65 citations
,
February 2011 in “Molecular cancer therapeutics” This study reported that the novel AKT inhibitor CCT128930 demonstrated significant antitumor activity in human cancer cell lines and xenografts, highlighting its potential as an anticancer therapy.
61 citations
,
September 2010 in “Genomics” This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.
58 citations
,
September 2019 in “EMBO Molecular Medicine” This study found that the CDK4/6 inhibitor palbociclib may protect human hair follicles from the damaging effects of taxane chemotherapy by inducing G1 arrest in stem/progenitor cells.
58 citations
,
October 2001 in “Dermatologic Clinics” This review discusses the categorization of hair loss and increased hair density disorders related to systemic diseases and reports no clinical results, emphasizing the potential diagnostic value of history, physical examination, and histopathologic data.
54 citations
,
September 2012 in “Dermatologic Clinics” This review discusses possible medication-induced hair loss and the need to exclude other confounding factors like stress and illness; it reports no new clinical findings and emphasizes careful assessment before attributing hair loss to medications.
45 citations
,
November 2017 in “Biomaterials” This study demonstrated a method for large-scale preparation of self-sorted hair follicle germs in vitro, which successfully generated hair follicles when transplanted into the skin of nude mice.
43 citations
,
November 1988 in “The Journal of Comparative Neurology” This study examined the sensory innervation of hair follicles in the furry skin of rat hindlimbs, finding significant differences among hair types in their innervation patterns and densities.