research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
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research Review of Pharmacological Effects of Myrtus Communis L. and Its Active Constituents
Myrtle has various health benefits and potential for medicine development.
research Treatment of Hyperandrogenic Alopecia in Women
Flutamide may slightly improve hair loss in women, but finasteride does not work.
research Role of 5α-Reductase in Health and Disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders
S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD
Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia
Early onset hair loss linked to genetics and androgen levels.
research Roles of Steroid Sulfatase in Brain and Other Tissues
Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.
research 5α-Reductase Inhibitors and Prostatic Disease
5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.
research Antiandrogen Therapy for Skin and Hair Disease
Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.
research The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals
The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.
research FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
research Early Embryonic Exposure of Freshwater Gastropods to Pharmaceutical 5-Alpha-Reductase Inhibitors Results in a Surprising Open-Coiled 'Banana-Shaped' Shell
Certain drugs change freshwater snail shells to a "banana" shape.
research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
research Epidemiological Assessment of Testosterone Levels in Women: A Factorial Analysis of Cell Proliferation
High testosterone levels in 20% of the women studied may indicate PCOS, while 80% had low levels with potential health impacts.
research Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia
Minoxidil with caffeine works better for hair loss than minoxidil alone.
research Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders
Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.
research Cardiac and Brainstem Neuroinflammatory Pathways Account for Androgenic Incitement of Cardiovascular and Autonomic Manifestations in Endotoxic Male Rats
Testosterone plays a big role in heart and nervous system damage caused by inflammation in male rats, suggesting that blocking testosterone production could help manage this condition.
research Treatment Options for Polycystic Ovary Syndrome
Different treatments for PCOS focus on the specific symptoms, with weight loss and lifestyle changes being important.
research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ
Sex hormones, especially androgens, play a key role in causing acne.
research Androgens and Ovarian Function: Translation from Basic Discovery Research to Clinical Impact
Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.
research Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats
Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.
research Serum Concentrations of Dehydroepiandrosterone-Sulfate in Men with Androgenetic Alopecia
Men with male pattern baldness don't necessarily have high levels of Dehydroepyandrosterone-sulfate, and there's no link between its levels and the severity of hair loss.
research Intracrine Androgen Biosynthesis, Metabolism, and Action Revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
research The Role of 5-Alpha-Reductase Inhibition in Suppressing Progression of Male Androgenetic Alopecia and the Potential Application of Saw Palmetto Extracts
Saw palmetto extracts might help treat male hair loss and need more research.
research Ovine Placental Steroid Synthesis and Metabolism in Late Gestation
Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.
research Intracrine and Myotrophic Roles of 5α-Reductase and Androgens
Muscles can make their own androgens, which may help muscle growth.
research Genetic and Molecular Aspects of Androgenetic Alopecia
Androgenetic alopecia is mainly caused by genetic factors and increased androgen activity, leading to hair follicle miniaturization.
![Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear](/images/research/861159f1-7bd4-420c-a16b-4829458efe68/small/15592.jpg)
research Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear
The compounds tested could potentially treat hair loss and alopecia.
research Ficus Benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation
Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.