June 2024 in “Dermatology and therapy” This study reviewed recent advancements in using botulinum toxin for treating androgenetic alopecia and emphasized the need for further research to determine the most effective injection sites and depths, as current strategies show inconsistent results.
February 2026 in “Bioengineering” This study concluded that repeated platelet-rich plasma injections provided greater and more consistent improvements in stress urinary incontinence symptoms compared to pelvic floor muscle training.
July 2023 in “Journal of personalized medicine” This study reports that a single intradermal injection of autologous adipose-derived stem cells improved visible aging signs such as wrinkles and pore size on facial skin for over a year in eight patients, with in vitro data suggesting muscle involvement in the rejuvenation process.
52 citations
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January 2023 in “Toxins” This narrative review discusses expert consensus on the optimal use of botulinum toxin injections for cosmetic applications in facial and oral-maxillofacial areas across Asian and Caucasian populations, highlighting injection techniques, effective doses, historical context, and potential complications.
29 citations
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March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)” This study observed that isoproterenol directs hair-follicle-associated pluripotent stem cells to differentiate into cardiac muscle cells in large numbers, forming tissue sheets of beating heart muscle cells in culture.
5 citations
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August 2005 in “Anatomy and Embryology” This study found that concentrated clusters of noradrenergic nerve fibers form a longitudinal linear system in rat skin, particularly innervating arrector pili muscles.
15 citations
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February 2000 in “Journal of Cutaneous Pathology” This study suggests that the anchorage of the arrector pili muscle to the extracellular matrix is likely mediated by α5β1 integrin, with α1β1 integrin involved in muscle cell-cell adhesion.
March 2022 in “Research Square (Research Square)” This study found that 4-aminopyridine significantly improved skin wound healing by enhancing wound closure, tissue regeneration, and cellular interactions involved in repair processes.
November 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that 4-aminopyridine, a potassium channel blocker, greatly improves skin wound healing by accelerating wound closure, enhancing tissue regeneration, and promoting hair follicle neogenesis.
103 citations
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March 2015 in “Nature Communications” This study identified a genetic locus associated with idiopathic scoliosis in females, which might influence spinal gene expression and was previously linked to protection from early-onset alopecia.
June 2024 in “Skin Research and Technology” In this study, patients with androgenetic alopecia who received type A botulinum toxin treatment showed increased follicle width and length at the vertex and left frontal area over three months, but no significant changes in follicle or hair count compared to the control group.
8 citations
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September 2024 in “International Journal of Molecular Sciences” This review discusses how polymers can be customized to develop biomaterials that mimic the extracellular matrix, exploring their potential in biomedical and biotechnological applications by triggering cell functions similar to natural physiological systems.
5 citations
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December 2022 in “Toxins” This review discusses the structural properties, pharmacological effects, and clinical applications of neurotoxins on synapses, reporting no new experimental results.
2 citations
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May 2024 in “Journal of science and medicine in sport” This position statement reviews the role of exercise professionals in managing PCOS and provides recommendations for physical activity, but it reports no new clinical findings.
December 2025 in “Saudi Journal of Medicine and Public Health” In this study, Saudi Arabian adults experienced high rates of long-term complications and significant weight regain more than 5 years after bariatric surgery, emphasizing the need for ongoing follow-up and nutritional management to address these issues.
September 2024 in “World Journal of Clinical Oncology” Chemotherapy with docetaxel and cisplatin can cause severe low potassium, requiring careful monitoring and treatment.
1 citations
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March 2021 in “medRxiv (Cold Spring Harbor Laboratory)” This study provided insight into unexpected uses and abuse of oral contraceptive pills by Jordanian males, primarily for bodybuilding, as reported by community pharmacists.
February 2026 in “Bioengineering” This study indicates that while EV-based therapies are advancing towards clinical use in regenerative medicine, addressing methodological and regulatory hurdles is essential to fully harness their therapeutic potential.
21 citations
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February 2016 in “Reproductive Biomedicine Online” This review examines how genetic variants associated with polycystic ovary syndrome affect reproductive success differently in men and women, supporting the theory that intralocus sexual conflict may explain its persistence.
3 citations
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May 2021 in “PloS one” This study found that Jordanian males use oral contraceptive pills, particularly for bodybuilding, based on recommendations from gym coaches, highlighting unexpected uses of these medications.
June 2014 in “British Journal of Dermatology” Eczema patients have a lower skin lipid to protein ratio, older and longer-staying hospital patients are more likely to get pressure ulcers, hair loss in AGA is linked to muscle degeneration, vitamin D deficiency is common in alopecia areata and linked to its severity, standard liver tests don't effectively detect fibrosis in psoriasis patients on methotrexate, and bullous pemphigoid patients have a higher death risk but combination therapy may reduce it.
1 citations
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May 2021 in “BMC Proceedings” This study found that frequent attenders at Cork University Hospital's emergency department accounted for a disproportionate amount of visits and were more likely to require admission for further care.
45 citations
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August 2018 in “Journal of Lipid Research” This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.
46 citations
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September 2014 in “Tissue engineering. Part A” This study found that a 3D Matrigel culture technique for dermal papilla cell spheroids can enhance hair follicle inductivity and induce hair-like fiber differentiation in vitro, even with high-passage cells.
48 citations
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May 2015 in “NPJ microgravity” In this study, mice exposed to prolonged space conditions demonstrated skin atrophy, altered hair follicle cycles, and significant changes in the gene expression associated with skin muscle health.
14 citations
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October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
8 citations
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September 2022 in “Biointerface Research in Applied Chemistry” This review examines the pharmacological potential of quinoline alkaloids from Cinchona bark for developing new drugs and cosmetics but reports no new findings.
3 citations
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March 2013 in “International Journal of Clinical Practice” Combination therapy for 9+ months maintains symptom improvements after stopping alpha-blockers or finasteride.
April 2022 in “International Journal of Health Sciences (IJHS) (En línea)” In this study, injection of cross-linked hyaluronic acid into the upper eyelid significantly improved the appearance of sunken and hollowed eyes in participants over a period of more than one year, with follow-ups at two weeks and three months.
24 citations
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September 2002 in “Dermatologic Surgery” This study describes the anatomy of arrector pili muscles in scalp hair follicular units, proposing a model where a single muscle structure is shared by all follicles within a unit.