15 citations
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August 2014 in “Journal of dermatological science” This study found that puerarin, derived from Pueraria thunbergiana, may stimulate melanogenesis and prevent follicular depigmentation in a hair graying mouse model.
4 citations
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August 2023 in “Journal of Cosmetic Dermatology” Gynostemma pentaphyllum extract may help grow hair and prevent graying.
December 2024 in “Antioxidants” This study found that external and internal luteolin treatments reduced hair graying in model mice by mitigating age-related dysfunction in hair stem cell signaling, suggesting potential practical applications for anti-graying treatment in humans.
67 citations
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August 2013 in “International Journal of Cosmetic Science” This review discusses the role of oxidative stress in hair greying and suggests that understanding melanocyte susceptibility at different follicular locations may help develop therapies for preventing and reversing the process; it reports no new experimental results.
In this report, a unique case of premature graying in a 32-year-old male, with onset at age 15 and a distinctive fractal pattern, was presented, highlighting the need for further investigation into its potential causes and mechanisms.
September 2017 in “Journal of Investigative Dermatology” In this study, the authors found that a botanical extract with anti-inflammatory and anti-oxidative properties stabilized hair loss and preserved natural hair pigmentation and strength over six months.
This study found that some white or grey hairs can naturally regain pigmentation, suggesting hair greying may be reversible in certain conditions linked to psychological stress.
13 citations
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December 1940 in “The journal of nutrition/The Journal of nutrition” In this study, silver foxes given a yeast "filtrate factor" supplement retained their fur and normal pelts, while those without it experienced fur loss and thymus abnormalities.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This abstract promotes a 100% natural hair oil, claiming it effectively reduces hair loss, promotes thicker growth, and provides long-lasting results for all hair types by nourishing the scalp and strengthening roots.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source does not report actual study results but promotes an anti-hair fall oil claimed to nourish the scalp, strengthen roots, and promote hair growth with herbal extracts, suitable for all hair types.
3 citations
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October 2007 in “Expert Review of Dermatology” This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.
210 citations
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May 2006 in “The FASEB journal” This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.
January 2026 in “Frontiers in Medicine” In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
May 2024 in “International Journal For Multidisciplinary Research” The study developed a hair cream using extracts from plants like Hibiscus rosa sinensis and Nigella sativa, reporting that it may protect the scalp and hair by providing antimicrobial effects, promoting hair growth, and preventing hair fall and graying.
2 citations
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June 2020 in “Journal of Drug Delivery and Therapeutics” This article discusses various hair-related issues, such as dandruff and hair loss, and outlines potential solutions, highlighting the need for personalized treatments and cost-effective approaches based on specific hair problems.
November 2023 in “International Journal For Multidisciplinary Research” This review explores how herbal hair oils made from ingredients like amla and hibiscus may offer benefits such as reducing hair loss and dandruff, but these are summarized from existing research rather than new experimental data.
January 2014 in “Journal of Pigmentary Disorders” This review discusses age-related and environmental factors affecting scalp hair changes in women, highlighting diagnostic complexities and ongoing research into targeted treatments, without reporting new clinical results.
7 citations
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January 2020 in “Nature” This study found that stress-induced signaling from the sympathetic nervous system in mice led to the depletion of stem cells in hair follicles, resulting in premature greying.
May 2026 in “Iconic Research and Engineering Journals” This review concluded that polyherbal hair oils, using key medicinal plants, may offer a validated and sustainable alternative to synthetic cosmetics for hair and scalp health, with potential for industrial standardization and clinical use.
August 2025 in “Asian Journal of Pharmaceutical Research and Development” This study scientifically evaluated a polyherbal hair oil made with amla, hibiscus, curry leaves, and coconut oil, finding it to have promising antioxidant and antimicrobial activity that may provide benefits like anti-hair loss and anti-dandruff effects.
March 2022 in “INDIAN JOURNAL OF APPLIED RESEARCH” This study found that the formulated shampoo using alcoholic extracts of Hibiscus rosa-sinensis demonstrated antimicrobial and antifungal activity and met all standard evaluation criteria, offering a potentially safer alternative to synthetic shampoos without harmful preservatives like paraben.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” In this review, researchers highlighted the potential of herbal hair oils made from rosemary (Rosmarinus officinalis) and black sesame (Sesamum indicum) as safe and effective alternatives to synthetic products, citing their antioxidant, anti-inflammatory, and nourishing properties that support scalp health and hair quality.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review highlights the potential of herbal hair oil prepared with rosemary and black sesame for scalp health, hair strength, and appearance, emphasizing their antioxidant and nourishing benefits as a natural alternative to chemical formulations.
21 citations
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December 2023 in “Journal of Investigative Dermatology” This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.
3 citations
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May 2022 in “Indian Journal of Dermatology” This study found that premature hair greying may be associated with low serum ferritin and raised anti-TPO levels.
November 2011 in “Informa Healthcare eBooks” Environmental, chemical, mechanical, and personal health factors can all damage hair and contribute to hair loss or changes in hair quality.
2 citations
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January 1997 in “Mapping” This study suggests that Gambogic Amide may act as an anti-hair greying and hair growth-promoting molecule in human hair follicles in vitro by maintaining pigmentation and stimulating hair shaft elongation.
15 citations
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November 2015 in “Trends in biotechnology” This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.
May 2009 in “Medical and surgical dermatology/Medical & surgical dermatology” Hair and nail conditions can stabilize or improve over time, and new treatments show promise.
November 2022 in “Journal of Investigative Dermatology” In this study, rapamycin was found to increase hair follicle pigmentation and prolong anagen duration in cultured human scalp hair follicles, suggesting it could be explored as an anti-greying agent.