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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride safely reduces excessive hair growth in women.

A woman's rare adrenal tumor caused high testosterone and cortisol levels, which normalized after the tumor was removed.

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.

Young women with nonclassic congenital adrenal hyperplasia may experience worse sexual function and mild depression compared to healthy women.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.

Combining flutamide and finasteride can reduce prostate weight and tumor growth, potentially benefiting treatments needing optimal DHT inhibition.

Women with congenital adrenal hyperplasia (CAH) have more sexual function issues than those with polycystic ovary syndrome (PCOS), but physical activity can improve sexual functioning in all women.

Finasteride and metformin both help treat PCOS, but using them together works best.

Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.

Clinical signs of excess male hormones and actual hormone levels in the blood do not always match in women with polycystic ovary syndrome.

Ovarian Hyperthecosis caused hypersexuality in an older woman and was successfully treated with surgery.

Taking biotin can lead to incorrect low results in free testosterone tests.

An 8-year-old boy's early puberty was caused by a rare hormone-secreting brain tumor, which was successfully treated with surgery.

Using lidocaine before keloid injections makes the treatment more comfortable for patients.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Estrogen therapy can reduce skin aging but has cancer risks.

Too much androgen can cause hair loss; finasteride may help.

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.