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    Glossary Androstenedione

    steroid hormone precursor to testosterone and estrogen

    Androstenedione, often referred to as Andro, is a steroid hormone that serves as a precursor in the biosynthesis of testosterone and estrogen. It is produced in the adrenal glands, ovaries, and testes, and plays a crucial role in the development of secondary sexual characteristics and reproductive function. Elevated levels of androstenedione can be associated with conditions like polycystic ovary syndrome (PCOS) and certain forms of adrenal hyperplasia.

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    1. Puberty in Boys: Correlation of Plasma Levels of Gonadotropins (LH, FSH), Androgens (Testosterone, Androstenedione, Dehydroepiandrosterone and Its Sulfate), Estrogens (Estrone and Estradiol) and Progestins (Progesterone and 17-Hydroxyprogesterone) The Journal of Clinical Endocrinology & Metabolism · 1975 · 96 citations
    2. Elevated serum androstenedione is associated with a more severe phenotype in women with polycystic ovary syndrome (PCOS) Hormones · 2014 · 28 citations
    3. The influence of obesity on Androstenedione to Testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia Gynecological Endocrinology · 2011 · 15 citations
    4. Scalp hair 17‐hydroxyprogesterone and androstenedione as a long‐term therapy monitoring tool in congenital adrenal hyperplasia Clinical Endocrinology · 2016 · 9 citations
    5. Androstenedione Strength and Conditioning Journal · 1999
    6. A Model for Predicting Polycystic Ovary Syndrome Using Serum AMH, Menstrual Cycle Length, Body Mass Index and Serum Androstenedione in Chinese Reproductive Aged Population: A Retrospective Cohort Study Frontiers in Endocrinology · 2022 · 5 citations
    7. 17α‐estradiol induces aromatase activity in intact human anagen hair follicles <i>ex vivo</i> Experimental Dermatology · 2002 · 94 citations
    8. Early breast development in girls after prenatal exposure to non‐persistent pesticides International Journal of Andrology · 2012 · 54 citations
    9. Hyperandrogenemia in women with polycystic ovary syndrome: prevalence, characteristics and association with body mass index Hormone Molecular Biology and Clinical Investigation · 2017 · 19 citations
    10. Urinary steroids in women with androgenic alopecia Clinical Biochemistry · 2000 · 16 citations
    11. Helpful diagnostic markers of steroidogenesis for defining hyperandrogenemia in hirsute women Steroids · 2007 · 14 citations
    12. Androgens in Women – Critical Evaluation of the Methods for Their Determination in Diagnostics of Endocrine Disorders Physiological Research · 2018 · 10 citations
    13. Design and Validation of a Sensitive Multisteroid LC-MS/MS Assay for the Routine Clinical Use: One-Step Sample Preparation with Phospholipid Removal and Comparison to Immunoassays International Journal of Molecular Sciences · 2022 · 9 citations
    14. LC-MS/MS improves screening towards 21-hydroxylase deficiency Gynecological Endocrinology · 2014 · 7 citations
    15. The influence of cyclosporine A therapy on sex hormone levels in pre- and post-menopausal women with primary biliary cirrhosis Journal of hepatology · 1994 · 4 citations
    16. Determination of steroid hormones in human hair as a retrospective biomarker with HPLC-MS/MS European journal of psychotraumatology · 2012
    17. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. Journal of Clinical Investigation · 1989 · 202 citations
    18. Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin 2001 · 196 citations
    19. SERUM STEROIDS AND PITUITARY HORMONES IN FEMALE PUBERTY: A PARTLY LONGITUDINAL STUDY Clinical Endocrinology · 1980 · 186 citations
    20. Gonadal Function Abnormalities in Sickle Cell Anemia Annals of Internal Medicine · 1976 · 163 citations
    21. Effects of Finasteride (MK-906), a 5<i>α</i>-Reductase Inhibitor, on Circulating Androgens in Male Volunteers* The Journal of Clinical Endocrinology and Metabolism · 1990 · 147 citations
    22. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertility and sterility · 1985 · 142 citations
    23. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    24. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009 · 105 citations
    25. Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism* The Journal of Clinical Endocrinology & Metabolism · 1990 · 100 citations
    26. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    27. Prevalence of polycystic ovaries in women with androgenic alopecia European journal of endocrinology · 2003 · 84 citations
    28. Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)∗ 1986 · 77 citations
    29. BENIGN PREMATURE ADRENARCHE: CLINICAL FEATURES AND SERUM STEROID LEVELS Acta Paediatrica · 1983 · 77 citations
    30. Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects Fertility and sterility · 1999 · 75 citations