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    Glossary Androgenicity

    ability of hormones to promote male traits and hair loss

    Androgenicity refers to the ability of certain hormones, known as androgens, to stimulate the development and maintenance of male characteristics. These hormones, such as testosterone, influence various bodily functions, including hair growth, muscle mass, and the deepening of the voice. In the context of hair, high androgenicity can lead to conditions like androgenetic alopecia, commonly known as male or female pattern baldness.

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    1. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006 · 1744 citations
    2. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report Fertility and Sterility · 2008 · 1540 citations
    3. Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred because of Clinical Hyperandrogenism The Journal of Clinical Endocrinology and Metabolism · 2006 · 352 citations
    4. Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2006 · 282 citations
    5. Cutaneous Androgen Metabolism: Basic Research and Clinical Perspectives 2002 · 233 citations
    6. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    7. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia Journal of Nutrition Health & Aging · 2013 · 211 citations
    8. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    9. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995 · 173 citations
    10. Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome Hypertension · 2007 · 166 citations
    11. Androgen biosynthetic pathways in the human prostate 2008 · 160 citations
    12. Androgen action on human skin – from basic research to clinical significance Experimental dermatology · 2004 · 147 citations
    13. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    14. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    15. A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia Clinical Endocrinology · 1994 · 135 citations
    16. Intracrine androgen biosynthesis, metabolism and action revisited Molecular and Cellular Endocrinology · 2017 · 131 citations
    17. The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003 · 130 citations
    18. Patterned androgenic alopecia in women Journal of The American Academy of Dermatology · 1988 · 130 citations
    19. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004 · 129 citations
    20. The role of androgen and androgen receptor in skin-related disorders Archives of Dermatological Research · 2012 · 124 citations
    21. Androgen sensitivity gateway to COVID‐19 disease severity Drug Development Research · 2020 · 123 citations
    22. Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations Calcified Tissue International · 1997 · 123 citations
    23. Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome Human Reproduction · 2009 · 119 citations
    24. Platelet-rich plasma in androgenic alopecia: Myth or an effective tool Journal of Cutaneous and Aesthetic Surgery · 2014 · 115 citations
    25. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 108 citations
    26. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009 · 105 citations
    27. Androgen‐induced neurite outgrowth is mediated by neuritin in motor neurones Journal of Neurochemistry · 2004 · 104 citations
    28. Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia British Journal of Dermatology · 1985 · 101 citations
    29. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    30. Androgen excess is the key element in polycystic ovary syndrome Fertility and Sterility · 2003 · 99 citations