June 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Six new risk spots for early hair loss were found, which also link to Parkinson's disease and lower fertility. Two genes, FOXA2 and HDAC4, could be new treatment targets. Hair loss might also be connected to heart disease, metabolic syndrome, and prostate cancer.
January 2012 in “Faculty of Health; Institute of Health and Biomedical Innovation” This study found six new genetic factors linked to early-onset androgenetic alopecia and its association with increased risk of Parkinson's disease and decreased fertility.
3 citations
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January 2019 in “International Journal of Trichology” This study suggests that female pattern baldness may be a marker for increased risk of coronary artery disease events among women.
24 citations
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January 2013 in “Indian Dermatology Online Journal” This study found that males with androgenetic alopecia had a higher risk of coronary artery disease, with significant differences in several lipid and blood pressure markers compared to controls.
March 2021 in “Journal of Babol University of Medical Sciences” This study found that men with androgenetic alopecia had a higher frequency of fatty liver disease compared to those without hair loss.
January 2004 in “Journal of Clinical Dermatology” This study found significant differences in serum total lipid, phospholipid, and triglyceride levels between patients with androgenetic alopecia and those without but no differences in LDL, HDL, or total cholesterol.
119 citations
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November 2009 in “Human Reproduction” This study found that women with polycystic ovary syndrome have a higher prevalence of non-alcoholic fatty liver disease and increased androgen bioavailability may be involved alongside metabolic factors.
6 citations
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May 2016 in “Urolithiasis” This study found that the risk of urinary stone disease increased significantly in patients with severe androgenetic alopecia, and that testosterone deficiency was more frequent among these patients.
November 2025 in “Scientific Reports” This study found that metabolic dysfunction-associated steatotic liver disease is linked to a higher risk of androgenetic alopecia, especially in women and individuals with certain lifestyle patterns.
June 2025 in “Indian Dermatology Online Journal” This study found that as the severity of androgenetic alopecia increased, the prevalence and severity of seborrheic dermatitis also increased.
February 2025 in “Pharmaceuticals” This study found that supplementing myo-inositol with microlipodispersed magnesium significantly improved acne and hirsutism in women with PCOS by reducing BMI, testosterone, and DHEAS levels, also enhancing quality of life without side effects, over 6 months.
34 citations
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March 1999 in “Journal of The European Academy of Dermatology and Venereology” This study found significant differences in serum lipoprotein (a) and triglyceride levels between men with androgenetic alopecia and those with normal hair, suggesting a need for dermatologists to monitor lipid profiles in these patients.
93 citations
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January 2000 in “Annals of Medicine” This discussion reviews the molecular mechanisms of ADP-induced platelet activation and suggests the P2Y1 receptor as a promising target for developing new antithrombotic drugs, without reporting new research findings.
114 citations
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March 2018 in “PLOS Medicine” This study found that women with polycystic ovary syndrome have higher rates of nonalcoholic fatty liver disease, with androgen excess contributing to the risk.
March 2026 in “Pakistan Armed Forces Medical Journal” This study found that trichoscopy positively correlates with disease severity in both male and female patients with androgenetic alopecia, suggesting its usefulness in early diagnosis and assessment.
March 1999 in “Journal of The European Academy of Dermatology and Venereology” Baldness may indicate higher heart disease risk in men.
815 citations
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April 2010 in “The Journal of Clinical Endocrinology & Metabolism” This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.
123 citations
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May 2020 in “Drug Development Research” This article argues that androgen sensitivity could be a key factor in the severity of COVID-19, suggesting that trials with anti-androgen agents may be warranted.
2 citations
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January 2018 in “Australasian Medical Journal” This meta-analysis reviewed observational studies and found that androgenic alopecia, particularly in younger men, may be associated with an increased risk of heart disease.
1 citations
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January 2022 in “Dermatology Research and Practice” This study found that androgenetic alopecia negatively impacts the emotional and social well-being of Polish men, particularly younger individuals, with 66.7% reporting a significant effect on self-esteem.
1 citations
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January 2022 in “Journal of Biosciences and Medicines” This review discusses the roles of androgens and androgen receptor in skin diseases like acne and hirsutism, and highlights the promise of antiandrogen drugs, reporting no new clinical findings.
September 2017 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān” This study observed that individuals with androgenetic alopecia had abnormal correlations in hematologic parameters, suggesting a chronic, slowly progressing immune-related disorder tied to pubertal androgen secretion.
July 2015 in “Egyptian Journal of Dermatology and Venereology” This study concluded that patients with androgenetic alopecia may have a higher risk of cardiovascular diseases compared to people without this condition.
57 citations
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January 2004 in “Journal of Endocrinology” This study found no support for the idea that male-pattern baldness in female-to-male transsexuals indicates an increased risk of coronary heart disease through androgenic effects on classic risk factors.
July 2026 in “Journal of the American Academy of Dermatology” Androgenetic alopecia is not linked to higher heart disease risk.
65 citations
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November 2019 in “European Journal of Pharmacology” This review discusses the role of anti-androgen therapies in cancer and other diseases and reports no new clinical results, highlighting both old and new generations of anti-androgens.
26 citations
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September 2020 in “Journal of the European Academy of Dermatology and Venereology” This publication is a letter discussing the association between an androgen receptor genetic variant and COVID-19 disease severity in hospitalized male patients, but it reports no new research results.
44 citations
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January 1999 in “Advances in pharmacology” This chapter reviews recent findings on androgen receptor function, structure, and interactions, highlighting post-translational modifications and mutations related to prostate cancer, but reports no new experimental results.
4 citations
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December 2021 in “Journal of Cosmetic Dermatology” This observational study found a significant association between the severity of androgenetic alopecia and worse COVID-19 outcomes in men compared to women, suggesting potential value in anti-androgen treatments.
January 2026 in “Dermatologic Therapy” In this study, researchers found that among 7,761 patients with androgenetic alopecia, behaviors such as insufficient sleep, poor dietary habits, alcohol consumption, heavy physical labor, and specific hairstyling choices were associated with increased severity of hair loss.