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Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.

Women with hyperandrogenism have higher androgen levels and lower SHBG, which may contribute to conditions like excessive hair growth and early puberty.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

Clascoterone cream could be used for other skin conditions affected by hormones.

Endocrine disruptors may cause early hair loss.

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

Minoxidil is an effective and safe treatment for common hair loss when applied to the skin, but more research is needed for optimal use.

Antiandrogens may help treat conditions like excessive hair growth, prostate tumors, male baldness, and acne by blocking male hormone effects.

A new, efficient method has been developed to detect darolutamide and thalidomide, drugs used for certain hair loss and prostate cancer treatments, in pharmaceuticals and body fluids.

New genes and pathways are important for testosterone production and male sexual development.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

The document concludes that diagnosing and treating Congenital Adrenal Hyperplasia is complex and requires a team approach due to its effects on the skin and other symptoms.

Testosterone affects stress hormone levels differently in adolescent and adult male rats.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, which could be a new target for treating hair loss and other skin conditions driven by testosterone.

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.

Finasteride helps treat hair loss by blocking enzyme activity.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.