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    Glossary Anagen Hair Follicles

    phase where hair actively grows

    Anagen hair follicles, also known as growing hair follicles or active hair follicles, are in the phase of the hair growth cycle where the hair is actively growing. This phase can last anywhere from 2 to 7 years, during which the hair shaft is continuously produced by the follicle, resulting in longer hair. This is the most prolonged phase of the hair cycle and is crucial for determining the length of the hair.

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    1. Effect of <i>Plantago asiatica L</i>. extract on the anagen phase in human hair follicle dermal papilla cells Journal of Cosmetic Dermatology · 2023 · 5 citations
    2. Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021 · 28 citations
    3. Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice International Journal of Radiation Biology · 2013 · 6 citations
    4. Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice Institutional Repositories DataBase (IRDB) · 2013
    5. Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice Institutional Repositories DataBase (IRDB) · 2013
    6. Histochemistry of the human hair follicle with consideration of anagen phases I to VI Acta Histochemica · 1992 · 18 citations
    7. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study Dermatology practical & conceptual · 2017 · 8 citations
    8. PDGF isoforms induce and maintain anagen phase of murine hair follicles Journal of Dermatological Science · 2006 · 136 citations
    9. The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered <i>Hoxc</i> gene expression in the ears Veterinary Dermatology · 2008 · 10 citations
    10. CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis Journal of Dietary Supplements · 2014 · 3 citations
    11. Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial MEDS Public Health and Preventive Medicine · 2025
    12. 575 An extract of Leontopodium alpinum prolongs anagen phase in human hair follicles ex vivo Journal of Investigative Dermatology · 2021
    13. Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling Journal of Microbiology and Biotechnology · 2025
    14. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles International Journal of Molecular Medicine · 2011 · 28 citations
    15. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles Pharmacological Reports · 2017 · 14 citations
    16. Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model International Journal of Molecular Sciences · 2020 · 2 citations
    17. 1386 Estetrol prolongs anagen in healthy female scalp hair follicles by positively modulating dermal papilla functions and generation of progenitor stem cells ex vivo 2023
    18. 704 Is intrafollicular autophagy an essential mechanism that permits human hair follicles to remain in prolonged anagen in vivo? Journal of Investigative Dermatology · 2016
    19. Effect of Escin in Human Hair Follicular Organ Culture: Prolonged Anagen Phase Chonnam Medical Journal · 2026
    20. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    21. Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance Journal of Investigative Dermatology · 2021 · 12 citations
    22. 76532 Estetrol (E4) prolongs anagen in healthy and female pattern hair loss hair follicles ex vivo Journal of the American Academy of Dermatology · 2026
    23. Immunohistochemical analysis of tissue remodelling during the anagen—catagen transition of the human hair follicle British Journal of Dermatology · 1997 · 23 citations
    24. Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models Current Topics in Nutraceutical Research · 2021
    25. 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing Journal of Investigative Dermatology · 2016 · 1 citations
    26. The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles Open Life Sciences · 2023
    27. 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase Journal of Investigative Dermatology · 2022
    28. Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair Experimental Dermatology · 2014 · 30 citations
    29. Single-Cell Transcriptomic Identification of a Proliferative Intermediate State During Early Anagen Hair Follicle Regeneration Genes · 2026
    30. Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle The EMBO Journal · 2000 · 305 citations