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    Glossary Alpha-blockers

    medications that relax blood vessels by blocking norepinephrine

    Alpha-blockers, also known as alpha-adrenergic antagonists, are medications that relax certain muscles and help small blood vessels remain open. They work by blocking the action of norepinephrine, a hormone that tightens the muscles in the walls of smaller arteries and veins. This can improve blood flow and lower blood pressure, making them useful in treating conditions like hypertension and benign prostatic hyperplasia (BPH).

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    1. A Comparison of Varying alpha-Blockers and Other Pharmacotherapy Options for Lower Urinary Tract Symptoms. PubMed · 2005 · 52 citations
    2. Prostate cancer incidence among finasteride and alpha-blocker users in the Finnish Prostate Cancer Screening Trial British Journal of Cancer · 2009 · 49 citations
    3. Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function Current Urology Reports · 2014 · 11 citations
    4. COMPARISON OF FINASTERIDE AND ALPHA‐BLOCKERS AS INDEPENDENT RISK FACTORS FOR ERECTILE DYSFUNCTION International Journal of Clinical Practice · 2003 · 9 citations
    5. Comparison of Different Alpha-blocker Combinations in Male Hypertensives with Refractory Lower Urinary Tract Symptoms Korean Journal of Andrology · 2011 · 8 citations
    6. Effect of dose reduction of dutasteride in combination with alpha-blockers in patients with lower urinary tract symptoms/benign prostatic enlargement Urology Annals · 2024 · 2 citations
    7. IsoPSA Performance Characteristics are Unaffected by 5-Alpha Reductase Inhibitors or Alpha-Blockers: Results From the IsoPSA Validation Study Urology · 2023 · 2 citations
    8. Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis International Neurourology Journal · 2025
    9. Alpha Blocker and 5-Alpha Reductase Inhibitor Prescribing Habits among Urologists and Primary Care Physicians Urology Practice · 2019
    10. Alpha-blockers/finasteride: no benefit in ED Reactions Weekly · 2003
    11. Sexual Dysfunctions Related to Drugs Used in the Management of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Narrative Review on α-Blockers and 5-Alpha Reductase Inhibitors Uro · 2021 · 6 citations
    12. Long-term efficacy and safety of the dual 5-alpha reductase blocker dutasteride on male androgenetic alopecia patients Journal of Dermatology · 2016 · 6 citations
    13. Benign Prostatic Hyperplasia Pharmacotherapy and Incident Ocular Surface Disease: Comparative Risk of Alpha-Blockers vs 5-Alpha Reductase Inhibitors Urology · 2026
    14. [Two drugs have a better outcome. Finasteride plus alpha blocker improves urine flow]. PubMed · 2003
    15. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    16. Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015 · 15 citations
    17. Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature Archivio Italiano di Urologia e Andrologia · 2020 · 14 citations
    18. The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs). Clinical Epidemiology · 2021 · 6 citations
    19. A retrospective study of clinical outcomes of α-blocker or finasteride monotherapy followed by combination therapy: determination of the period of combination therapy of α-blocker and finasteride International Journal of Clinical Practice · 2013 · 3 citations
    20. Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia Clinical Breast Cancer · 2019 · 1 citations
    21. Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement Postgraduate Medicine · 2026
    22. Depression risk of 5-alpha reductase inhibitors: A systematic review and meta-analysis with a focus on comparator groups medRxiv (Cold Spring Harbor Laboratory) · 2025
    23. MP09-16 5-ALPHA REDUCTASE INHIBITORS FOR MALE LOWER URINARY TRACT SYMPTOMS: A COCHRANE SYSTEMATIC REVIEW AND META-ANALYSIS 2017
    24. Faculty Opinions recommendation of Association between 5-alpha reductase inhibition and risk of hip fracture. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2008
    25. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    26. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    27. Review: Adding α<sub>1</sub>-blockers to 5α-reductase inhibitors improves lower urinary tract symptoms in men Annals of Internal Medicine · 2014
    28. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) The Aging Male · 2026
    29. No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study Journal of the American Academy of Dermatology · 2026
    30. Epidemiology and treatment modalities for the management of benign prostatic hyperplasia Translational Andrology and Urology · 2019 · 110 citations