October 2025 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study highlighted the significant role of VSM in cochlear aging, suggesting that changes in its structure and composition may contribute to the development of various pathologies, including congenital hearing disorders, while also identifying the need for further research on VCM-associated molecules.
241 citations
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March 2000 in “The Journal of Urology” This review discusses the concept of andropause, preferring the term "androgen decline in the aging male" (ADAM), and emphasizes the need for urologists to recognize its manifestations and manage its treatment, but reports no new clinical results.
30 citations
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March 2010 in “European Journal of Dermatology” This article discusses hair loss in postmenopausal women as often being multifactorial, reviewing various conditions affecting this group, but reports no new research findings.
20 citations
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February 2023 in “Biology” This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.
8 citations
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September 2016 in “Reviews in Endocrine and Metabolic Disorders” Skin health and diseases are closely linked to metabolic processes.
September 2023 in “Cells tissues organs” In this study, researchers observed that in mice, as they age beyond 200 days, unusual curved hair follicles and increased white hairs emerge, indicating stem cell-related changes in keratinocyte and melanocyte characteristics, providing insights into hair aging processes.
October 2018 in “Oncology Times” This commentary discusses the cultural and biological significance of hair, intertwined with humorous and poignant anecdotes from cancer care, and reports no new research findings.
6 citations
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May 2020 in “Nutrients” This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.
8 citations
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January 2013 in “BioMed Research International” This study observed that both Factor XIIIa+ dermal dendrocytes and microvasculature size decreased with scalp aging and that alopecia changes resembled stress-induced premature senescence.
October 2025 in “Research Square (Research Square)” This study found that perifollicular vascularization adapts to physiological changes, with minoxidil enhancing capillary growth around the dermal papilla and aging-related factors inhibiting it, suggesting potential interventions for hair loss.
December 2025 in “Brazilian Journal of Hair Health” This integrative review developed a Spiral Model to better represent human hair follicle dynamics and aging, which may assist in distinguishing natural aging from pathological changes and improving trichological interventions.
2 citations
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October 2009 in “The FASEB Journal” This article reviews the historical and scientific perspectives on the phenomenon of stress-induced changes in hair color and reports no evidence supporting the idea that holding or resigning from political office accelerates human aging or hair graying.
April 2026 in “Inflammation and Regeneration” This study found that androgen inactivation pathways in scalp sebaceous glands change with age, specifically noting that AKR1C expression, including AKR1C4 previously thought liver-specific, declines with age and is sex dependent, which could impact hair follicle health during aging.
January 2025 in “Mansoura Medical Journal” In this animal study, researchers observed that both aging and lower androgen levels in male albino rats led to significant structural changes in meibomian glands, including reduced acinar cell size, diminished meibum secretion, and increased collagen deposition.
19 citations
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July 2009 in “Clinical and Experimental Dermatology” This article discusses how the balding scalp's exposure to UV and near-infrared light may accelerate aging, with changes detectable under ultraviolet light; it presents no new clinical findings.
3 citations
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April 2025 in “Science Advances” This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.
December 2024 in “International Journal of Maxillofacial Imaging” This abstract outlines the goal of various face cosmetic surgery procedures, such as rhinoplasty and facelifts, which are used to enhance facial appearance and address aging-related changes. However, specific study results are not provided.
1 citations
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February 2025 in “Scientific Reports” In this study, researchers developed a three-dimensional ultrastructural analysis tool using serial block-face scanning electron microscopy to reveal detailed nerve networks and muscle structures in human skin tissues, demonstrating the technique's potential to study structural changes in aging or disease.
This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.
June 2026 in “Preprints.org” This study found that in healthy young men, oral minoxidil at 5 mg/day led to increased carotid intima-media thickness and vascular aging, suggesting potential cardiovascular side effects at higher doses. A dose-dependent effect was observed, while dutasteride displayed a favorable vascular profile without significant changes.
55 citations
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April 2022 in “Journal of Molecular Medicine” This review discusses the relationship between aging, chronic inflammation, and immunosuppression, suggesting that these interconnected processes may contribute to tumorigenesis and premature aging, but reports no new experimental results.
40 citations
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December 2011 in “British Journal of Dermatology” This article reviews how chronological aging affects female scalp hair growth and suggests that multiple factors, including environmental influences, contribute to female pattern hair loss; no new clinical results are presented.
January 2010 in “Chinese Journal of Aesthetic Medicine” The study observed increased melanin and signs of skin aging in melasma-afflicted skin, with strong CK10 expression in the upper basal epidermis, potentially linked to excessive epidermal cell differentiation and aging.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Aging affects hair density and skin health, and Behcet's disease, a complex condition with no specific test, involves sores and systemic issues, treated with various medications.
March 2024 in “Jagiellonian University Repository (Jagiellonian University)” This study found that DNA methylation-based age predictors and lifestyle factors significantly affect perceived age and external visible characteristics in the aging process, with implications for forensic and anti-aging cosmetic applications.
July 2020 in “Experimental Dermatology” This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.
21 citations
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July 2001 in “Clinics in dermatology” This review discusses the clinical use of nutraceuticals for skin aging in dermatological practices and reports no new clinical results.
33 citations
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August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses various biologics for hair aging but reports no agent capable of reversing the natural aging process of hair.
23 citations
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May 1984 in “Journal of the American Geriatrics Society” Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.
14 citations
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March 2015 in “Facial plastic surgery clinics of North America” This review discusses various surgical techniques for rejuvenating the aging upper face, focusing on the assessment of individual structures and their relationships, but it reports no new clinical results.