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This study found that both Japanese male and female hair darkens with age, with significant sex differences in melanin composition and melanosome morphology influencing hair color.

This study found that the COVID-19 pandemic has heightened skin concerns, with women and young adults being particularly more affected in their attitudes toward their skin.

This scoping review evaluates the connection between hypoxia and declining sex hormonal signaling in middle-aged individuals, proposing a "middle-aging hypovascularity hypoxia hypothesis" as a potential mechanism influencing age-related diseases, with implications for developing strategies to maintain healthspan.

This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.

This study found that sustained intracellular acidosis in mice was associated with shortened lifespan, early aging signs, and impaired autophagy.

This study suggests that hydroxypinacolone retinoate (HPR) may be an effective alternative to tretinoin for anti-aging skin treatments, offering similar collagen production benefits without increased skin irritation.

This study found that glycolic acid treatment reduced oxidative stress and inflammation in UV-induced skin photoaging in rats, promoting collagen recovery and reducing photoaging signs, potentially by inhibiting the PI3K/Akt and NF-κB pathways.

This study compared the effectiveness of different thread types in improving collagen profiles in UVB-exposed aging model rats, finding that PCL threads were more effective than PDO and PLLA in enhancing dermal collagen characteristics.

This study used computational modeling to identify key genes and miRs involved in cardiac aging, finding a strong relationship supported by literature and some experimental validation in aged mouse hearts.

This study found that testosterone applied to aging skin modestly reduced wrinkles and improved microscopic skin architecture, while ethinyl estradiol showed no effect and corticosteroids worsened skin aging changes.

This article discusses various dermatologic surgical methods for managing skin conditions but reports no clinical results; the authors note that some manifestations of senile skin are not amenable to these procedures.

This study's overview highlights that lifestyle factors like nutrition, sleep, physical activity, and social interactions can significantly enhance skin health with aging. The authors suggest social media campaigns promoting these habits could potentially improve skin well-being in the future.

This study found that a long-term astrocyte culture model can effectively study astrocyte senescence and suggests minoxidil as a potential candidate to regulate brain aging by normalizing dysregulated gene expression in aged astrocytes.

This study found that aging mice with an epidermal deletion of DNA methyltransferase 1 had a reduced number of hair follicles, due to decreased stem cell activation probability.

This study found that a newly developed keratin active ingredient effectively prevents aging damage in hair by strengthening its structure after exposure to simulated environmental stress.

This article provides a detailed review of minoxidil's pharmacological effects for treating androgenic alopecia but reports no new clinical results.

This review discusses the clinical aspects, diagnosis, and treatment options for androgenetic alopecia, ultimately calling for further research, particularly regarding older populations and possible health risks.

This study found that Hydroxypinacolone Retinoate (HPR) may alleviate UV-induced skin photoaging by enhancing collagen synthesis, reducing degradation, and modulating inflammatory and oxidative responses in a dose-dependent manner.

This source redefines anti-aging medicine as "precision healthspan pharmacology," suggesting that rather than just treating diseases or accepting aging, pharmacology should focus on expanding functional capacity across various health domains, while emphasizing the importance of fundamental physiological and psychosocial health factors.

This review synthesizes preclinical evidence suggesting that Centella asiatica may extend healthspan by modulating aging hallmarks, enhancing DNA repair, improving mitochondrial function, and reducing inflammation and oxidative stress, potentially paving the way for future gerotherapeutic strategies.

This study found that enhancing quercetin bioavailability with EubioQuercetin significantly improved external aging signs in mice and influenced gut microbiota and intestinal gene expression, suggesting potential modulation through the gut microbiota–intestinal barrier axis.

The study found that enhancing quercetin bioavailability with EubioQuercetin may amplify its anti-aging effects in mice by modulating the gut microbiota and improving intestinal barrier function.

In this study, O. forskahlii seed oil was found to promote hair growth in rats and exhibit anti-aging effects on human skin cells by enhancing fibroblast proliferation and inhibiting inflammation and enzyme activity, indicating potential for cosmetic use.

This narrative review highlights recent advancements in anti-ageing cosmetic procedures, emphasizing personalized interventions that improve patient outcomes and quality of life. The review synthesized evidence from 144 articles to assess the effectiveness and potential side effects of surgical and non-surgical techniques for facial rejuvenation.

In this review, the authors explored how various hormones, particularly IGF-1, GH, estrogens, retinoids, and melatonin, influence human skin aging, highlighting potential new avenues for anti-aging therapies beyond the currently utilized topical retinoids and estrogens.

Paclitaxel chemotherapy causes premature aging and damage to hair follicles, potentially leading to permanent hair loss.

This review evaluates current research on how hormonal changes due to aging impact voice quality, concluding the vocal cords are sensitive to hormonal fluctuations throughout life but reports no new clinical results.

This study found that dysregulation of the DNA damage response in stem cells is a common factor of aging, affecting tissues like the skin, brain, kidneys, and intestine.