November 2016 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)” This study found that Dendrobium sabin flower extracts, especially the methanolic one, demonstrated strong antioxidant and anti-aging properties without significant toxicity, suggesting its potential in treating photo-induced skin aging.
This study found that extracellular Granzyme B contributes to skin aging and impaired healing in ApoE knockout mice by degrading essential extracellular matrix components like decorin and fibronectin.
August 2010 in “Acupuncture & Electro-Therapeutics Research” In this study, using far-infrared oily cream for massage therapy was associated with increased normal cell telomere length and improvements in stress-induced hair and skin conditions.
October 2009 in “추계총회 및 학술대회” Natural Agiyeo Hair Cleaner may help hair grow in people with pattern baldness.
January 2008 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” Healthy aging can be promoted through physical activity, lifestyle changes, and certain treatments.
July 2007 in “Cancer biology & therapy” In this study, researchers found that deleting the ATR gene in adult mice led to signs of premature aging and reduced capacity for tissue renewal.
242 citations
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February 2016 in “Science” This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.
178 citations
,
June 1994 in “Journal of Investigative Dermatology” This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.
97 citations
,
March 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study suggests that there is a U-shaped relationship between vitamin D hormonal forms and aging, with an optimal serum calcidiol concentration needed to minimize aging-related chronic disease risk.
92 citations
,
November 2003 in “The Journals of Gerontology” This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.
80 citations
,
April 2006 in “Clinical Interventions in Aging” This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.
75 citations
,
March 2014 in “Journal of Investigative Dermatology” This study found that aging mice experience slower and more fragmented hair cycle waves, but transplanting aged skin to a young host can partially restore hair cycling, implicating extracellular factors.
66 citations
,
June 1997 in “The Laryngoscope” This article discusses advancements in managing the aging brow and forehead, reporting on a tailored problem-specific approach using both innovative technologies and traditional surgeries, but provides no new clinical results.
61 citations
,
September 1970 in “Journal of the American Geriatrics Society” In this study, anabolic and catatoxic steroids were reported to prevent weight loss, tissue calcification, and cardiac necrosis in a rat model of disturbed calcium metabolism and progeria-like syndrome.
59 citations
,
November 2010 in “Circulation Research” This review discusses the potential role of Wnt signaling in aging-related heart diseases and reports no clinical results.
55 citations
,
January 2007 in “Climacteric” This paper reviews guidelines discussed at a meeting about research and practice themes, but reports no new research findings.
38 citations
,
February 2021 in “Journal of Investigative Dermatology” This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.
31 citations
,
April 2019 in “Journal of Cutaneous Pathology” This review discusses the changes in hair follicles with aging, particularly graying due to decreased melanocyte activity, and suggests potential for hair repigmentation under certain conditions, but reports no new results.
28 citations
,
March 2020 in “Journal of ethnopharmacology” This study found that ginsenoside Rb1 treatment significantly reduced aging symptoms in mice by regulating cell cycle and apoptotic pathways, potentially linked to metabolic changes.
21 citations
,
February 2021 in “Frontiers in Endocrinology” This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.
20 citations
,
January 2015 in “Current problems in dermatology” This article discusses the aging-related changes in hair structure and function, and examines various treatments like light therapy, minoxidil, and finasteride aimed at mitigating hair thinning and loss, but reports no new clinical results.
20 citations
,
January 2012 in “Journal of Steroids & Hormonal Science” The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.
16 citations
,
March 2023 in “Clinical Cosmetic and Investigational Dermatology” This study demonstrated that regular use of LactoSporin cream for 10 weeks significantly reduced wrinkles and fine lines in healthy female participants, although improvements in skin elasticity and hydration were not significantly better than placebo when measured by certain instruments.
16 citations
,
July 2007 in “Facial Plastic Surgery Clinics of North America” This article reviews approaches to facial aging in Asian patients, discussing cultural perspectives and proposing a new paradigm of youthful appearance, but provides no new clinical results.
14 citations
,
December 2020 in “Journal of Investigative Dermatology” This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.
11 citations
,
June 2019 in “Tissue & Cell” This study indicates that COL17A1 plays a crucial role in the differentiation process of hair-follicle-associated pluripotent stem cells.
10 citations
,
December 2024 in “EXPERIMENTAL ANIMALS” This study found that aged C57BL/6 mice sub-strains exhibit distinct aging patterns, including differences in survival rates, body weight changes, and disease incidences, providing valuable insights for geriatric research using these mice models.
10 citations
,
October 2018 in “Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology” This study identified NM_026333 as a potential anti-aging gene that, when induced, may alleviate proton-induced aging symptoms in CF6-overexpressing and high salt-fed mice.
8 citations
,
April 2017 in “Journal of Dermatological Science” The study found that aging in hair follicle stem cells leads to hair follicle miniaturization and eventual hair loss in both wild-type mice and humans by proteolyzing type XVII collagen.
8 citations
,
January 2017 in “Elsevier eBooks” This review discusses the use of nutraceuticals in dermatology for preventing and reversing signs of skin aging, but it reports no new clinical results.