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    Glossary Advanced Glycation End-products

    harmful compounds formed when proteins or fats bind with sugars

    Advanced Glycation End-products (AGEs) are harmful compounds formed when proteins or fats combine with sugars in the bloodstream through a process called glycation. These compounds accumulate in various tissues and organs over time, contributing to aging and the development of chronic diseases such as diabetes, cardiovascular disease, and neurodegenerative disorders. AGEs can also affect skin elasticity and are implicated in hair follicle aging, potentially influencing conditions like alopecia.

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    1. Non-invasive evaluation of advanced glycation end products in hair as early markers of diabetes and aging Scientific Reports · 2025 · 4 citations
    2. Advanced glycation end-products inhibit mesenchymal-epidermal interaction by up-regulating proinflammatory cytokines in hair follicles European Journal of Dermatology · 2015 · 3 citations
    3. Potential of Natural Products in Hangeshashinto Water Extract on the Direct Suppression of Stomatitis Induced by Intra-/Extracellular Advanced Glycation End-Products International Journal of Molecular Sciences · 2025
    4. Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin Experimental Dermatology · 2015 · 10 citations
    5. Correlations between soluble receptor for advanced glycation end products and heme oxogenase-1 in post-COVID-19 patients with telogen effluvium Journal of the Egyptian Womenʼs Dermatologic Society · 2026
    6. Method for chronological recording of antigen appearance in human head-hair shafts and its use for monitoring glycation products in diabetes Journal of immunological methods · 2006 · 7 citations
    7. Compendium of polycystic ovarian syndrome and its relevance in glycation and diabetes Journal of experimental and clinical medicine · 2022 · 1 citations
    8. Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review Antioxidants · 2018 · 280 citations
    9. Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry Journal of Proteome Research · 2014 · 71 citations
    10. Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches Antioxidants · 2023 · 15 citations
    11. Oxidative stress and antioxidant markers in patients with alopecia areata: A comparative cross-sectional study Indian journal of dermatology, venereology, and leprology · 2022 · 3 citations
    12. RAGE and Its Ligands in Melanoma InTech eBooks · 2015 · 1 citations
    13. Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices International Journal of Molecular Sciences · 2026
    14. Regenerative Therapies for Cosmetic Dermatology for Patients with Diabetes Mellitus: Skin Aging, Aesthetic Concerns, and Evidence-Based Best Practices Preprints.org · 2026
    15. Evaluation of oxidative stress markers in Androgenetic Alopecia Patients Benha Journal of Applied Sciences · 2023
    16. Nutritive diet becomes unhealthy if taken in a wrong ratio: Scientific validation of Ayurvedic concept of “incompatible diet” (<i>Virrudh Aahar</i>) bioRxiv (Cold Spring Harbor Laboratory) · 2019
    17. Antiglicants Clinical approaches and procedures in cosmetic dermatology · 2017
    18. UV laser-induced fluorescence spectroscopy and laser Doppler flowmetry in the diagnostics of alopecia Proceedings of SPIE · 2016
    19. Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner International Journal of Dermatology and Clinical Research · 2019
    20. Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2019
    21. The compatibility of Bacillus thuringiensis Cry protein-solubilizing buffers with the droplet feeding method in fall armyworm larvae Journal of Invertebrate Pathology · 2019
    22. HMGB1 promotes hair growth via the modulation of prostaglandin metabolism Scientific Reports · 2019 · 12 citations
    23. Evaluation of the role of soluble receptors for advanced glycosylated end-products in polycystic ovarian syndrome Evidence Based Women Health Journal (Online) · 2016
    24. The skin landscape in diabetes mellitus. Focus on dermocosmetic management Clinical Cosmetic and Investigational Dermatology · 2013 · 31 citations
    25. Society News Journal of The Royal Society for The Promotion of Health · 2007
    26. Hair Growth Defects of Diabetic and Hypercholesterolemic Wistar Albino Rats and Amelioration of Fish Oil-Treatment Journal of Nutrition and Health · 2015
    27. Montagna Symposium 2014—Skin Aging: Molecular Mechanisms and Tissue Consequences 2015 · 9 citations
    28. Advances in Nanotechnology Research in Food Production, Nutrition, and Health Nutrients · 2025 · 5 citations
    29. Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging International Journal of Molecular Sciences · 2017 · 132 citations
    30. Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities International Journal of Molecular Sciences · 2025 · 2 citations