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    Glossary Adaptogen

    Adaptogens are natural substances, often derived from plants, that help the body adapt to stress and promote homeostasis. In the context of hair loss, adaptogens may play a role in reducing stress-related hair shedding and supporting overall hair health by balancing hormonal levels and enhancing resilience to environmental stressors. Key distinguishing characteristics of adaptogens include their ability to normalize physiological functions and their non-specific action, meaning they can benefit various bodily systems rather than targeting a single issue.

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    1. Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms Drug Design Development and Therapy · 2023 · 1 citations
    2. Adaptogenic herbal extracts for stress-induced dermatoses: a narrative review Archives of Dermatological Research · 2026
    3. Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages Experimental Dermatology · 2003 · 268 citations
    4. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors Proceedings of the National Academy of Sciences of the United States of America · 2014 · 130 citations
    5. Cultured Cells from the Adult Human Hair Follicle Dermis can be Directed Toward Adipogenic and Osteogenic Differentiation Journal of Investigative Dermatology · 2005 · 38 citations
    6. Fluoxetine Decreases the Proliferation and Adipogenic Differentiation of Human Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2015 · 24 citations
    7. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Stem Cell Research & Therapy · 2020 · 20 citations
    8. Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor Stem Cells Translational Medicine · 2015 · 11 citations
    9. DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages Stem cell research & therapy · 2020 · 8 citations
    10. Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow Cell regeneration · 2020 · 6 citations
    11. Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies Cells · 2023 · 4 citations
    12. YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2 动物学研究 · 2025 · 2 citations
    13. Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers FEBS open bio · 2019 · 2 citations
    14. Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement Journal of Cosmetic Dermatology · 2026
    15. TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs Stem Cell Research & Therapy · 2025
    16. Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation Development · 2025
    17. Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells Foods · 2025
    18. 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration Journal of Investigative Dermatology · 2024
    19. Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells Applied biological chemistry · 2024
    20. Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers Institutional Repositories DataBase (IRDB) · 2022
    21. Adipogenic Differentiation of Canine Hair Follicle Stem Cells (cHFSCs) Indian Journal of Animal Research · 2022
    22. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021
    23. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Research Square (Research Square) · 2020
    24. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Research Square (Research Square) · 2020
    25. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy 2020
    26. 1339 Mature adipocytes inhibit the antimicrobial function of dermal adipogenic stem cells: An explanation for impaired cutaneous defense in obesity Journal of Investigative Dermatology · 2018
    27. 0885 The androgen-THY1 axis mediates sexual dimorphism in dermal adipogenesis and fibrosis Journal of Investigative Dermatology · 2025
    28. Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82 Journal of Investigative Dermatology · 2017 · 53 citations
    29. Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses Scientific Reports · 2026
    30. Nutraceuticals Dermatologic Clinics · 2021 · 7 citations