September 2017 in “Journal of Investigative Dermatology” This study found that mackerel fermented fish oil protected human keratinocyte cells from UVB-induced oxidative stress by scavenging free radicals and reducing cellular damage.
This study found significant variability in the production and use of platelet-rich plasma and related products in Brazil, highlighting the need for regulatory measures to ensure safety.
December 2025 in “International Journal of Innovative Technologies in Social Science” This review outlines that minoxidil (topical and oral) and 5α-reductase inhibitors are the most effective treatments for androgenetic alopecia, with additional therapies like platelet-rich plasma and hair transplantation enhancing results, emphasizing the need for individualized, combination approaches.
1 citations
,
July 2023 in “Chinese Medicine” This study found that Shi-Bi-Man significantly promotes hair regeneration in cynomolgus monkeys by increasing hair follicle stem cells and up-regulating metabolic pathways.
638 citations
,
October 1997 in “Nature” 328 citations
,
November 2020 in “Nature Materials” This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.
265 citations
,
July 2012 in “Cell” This study found multipotent progenitors in sweat ducts that become unipotent after sweat gland development, highlighting distinct regenerative capabilities in adult glandular skin stem cell populations.
191 citations
,
September 2011 in “Cell stem cell” This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.
151 citations
,
November 2018 in “International Journal of Pharmaceutics” This review discusses various nanoparticles and nanoemulsions being investigated for transdermal drug delivery and reports no clinical results; it highlights potential applications in treating alopecia, wound healing, psoriasis, and melanoma.
150 citations
,
April 1999 in “Dermatologic Clinics” This article reviews the biological and physical principles of laser hair removal and reports that current laser systems do not consistently achieve permanent hair follicle destruction across treated areas.
124 citations
,
July 1997 in “Journal of Biological Chemistry” This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.
84 citations
,
February 2013 in “Clinica chimica acta” This review presents evidence that correlations exist between hair mineral imbalances and various diseases, though inconsistencies in results highlight the need for standardized preparation methods.
83 citations
,
January 2015 in “World Journal of Stem Cells” This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.
81 citations
,
February 2014 in “EMBO molecular medicine” This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.
77 citations
,
September 2017 in “Journal of Investigative Dermatology” This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.
73 citations
,
April 1999 in “Dermatologic Clinics” This article reviews patient selection and treatment protocols for various light-based hair removal systems but presents no new clinical results.
60 citations
,
July 2020 in “ACS Nano” This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.
47 citations
,
January 2016 in “MethodsX” This study found that while the reproducibility of hair cortisol measurements in captive chimpanzees was high, the fineness of homogenized hair, sample weight, and extraction time influenced absolute cortisol concentrations.
27 citations
,
January 2006 in “Colloids and Surfaces B: Biointerfaces” This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.
23 citations
,
January 2018 in “Elsevier eBooks” This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.
23 citations
,
December 2013 in “Molecular cancer therapeutics” This study found that AR-positive breast cancer cell lines are more sensitive to the dual PI3K/mTOR inhibitor NVP-BEZ235 compared to AR-negative cells.
20 citations
,
November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that IFN-γ plays a critical role in T cell activation and the pathogenesis of alopecia areata in C3H/HeJ mice.
18 citations
,
February 2020 in “Journal of pharmaceutical and biomedical analysis” This study using high-performance liquid chromatography reported that mice with more diverse gut microbiota had higher levels of specific compounds in hair compared to those with less diversity, with stress affecting certain plasma levels.
14 citations
,
July 2021 in “Bioscience Reports” In this study, activation of Tgr5 was found to improve alopecia areata and bone microstructure in mice by down-regulating the JAK1-STAT3 signaling pathway.
14 citations
,
September 2017 in “Hormones and behavior” This study found that the estrous cycle influences the effect of the δ-GABAAR agonist THIP in reducing binge drinking behavior in female mice, with receptor expression elevated during diestrus.
11 citations
,
April 2021 in “Cancers” This study identified a small molecule that activates GLI1, suppressing neuroblastoma cell growth, which may aid in developing new treatments for high-risk neuroblastoma cases.
11 citations
,
November 2023 in “Journal of Advanced Research” This study found that activating ALDH2, an enzyme that detoxifies acetaldehyde, promoted hair growth in hair follicles by reducing oxidative stress and enhancing cellular signaling pathways, suggesting a potential therapeutic approach for inducing hair regrowth.
10 citations
,
December 2018 in “Medical Science Monitor” This study suggests that the MAPK/ERK signaling pathway plays a role in the regulation of cell proliferation, apoptosis, and cycling in rat urethral plate fibroblasts affected by finasteride-induced hypospadias.
9 citations
,
January 1995 in “Aesthetic Plastic Surgery” This study observed that using a relaxed suture technique on scalp incisions may prevent linear scars by reducing pressure on upper stem cells.
6 citations
,
August 2022 in “International journal of molecular sciences” This study demonstrated that α-phellandrene promotes dermal papilla cell proliferation through a cAMP-mediated pathway and upregulates VEGF expression, suggesting its potential use in hair loss prevention.