17 citations
,
October 2006 in “Molecular and Cellular Endocrinology” This study found that the L457(3.43)R mutation in the human luteinizing hormone receptor increases phosphodiesterase activity, reducing hormonal response despite elevated basal cAMP levels.
11 citations
,
January 2017 in “Oxidative medicine and cellular longevity” This study found that antroquinonol inhibited CD8+ T cell proliferation and reduced proinflammatory cytokine secretion in vitro, while also ameliorating H2O2-induced depigmentation and resisting reductions in hair follicle length, skin thickness, and tyrosinase expression in mice.
9 citations
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June 2021 in “International Journal of Pharmaceutics” This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.
7 citations
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July 2019 in “International Journal of Molecular Sciences” This study found that PGA-4HGF nanoparticles enhanced hair growth in mice more effectively than 4HGF alone by increasing anagen phase duration and dermal papilla cell proliferation.
5 citations
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October 2024 in “International Journal of Biological Sciences” This study found that a specific fragment of AIMP1, secreted by hair follicle stem cells, activated dermal papilla cells, leading to enhanced hair regrowth and maintenance in mice.
2 citations
,
November 1998 in “Journal of The European Academy of Dermatology and Venereology” This study focused on the ultrastructural and immunohistochemical aspects of dermal mast cells in systemic mastocytosis and their interaction with the epidermal melanin unit.
1 citations
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October 2020 in “Journal of Cosmetic Dermatology” This study found that metabolic syndrome was more prevalent among androgenetic alopecia patients than controls, with higher serum RANTES levels suggesting a potential role in the syndrome's pathogenesis.
4 citations
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April 2024 in “Cellular and Molecular Biology” In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
32 citations
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August 2015 in “Journal of Investigative Dermatology” In this study using a mouse model, Prom1+ dermal papilla cells were found to regulate the size of the papilla via β-catenin communication but did not aid in dermal repair.
25 citations
,
March 2017 in “Archives of Dermatological Research” This study suggests that sinapic acid may promote hair growth in human hair follicle dermal papilla cells by activating specific signaling pathways and inducing the expression of growth factors.
19 citations
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January 2018 in “BioMed Research International” This study suggests that miRNAs, particularly miR-195-5p, may regulate the loss of hair follicle inductivity in cultured dermal papilla cells by suppressing the Wnt/β-catenin pathway.
19 citations
,
January 2016 in “Biological & Pharmaceutical Bulletin” This study found that Sargassum muticum extract and apo-9′-fucoxanthinone promoted hair growth in rat and mouse models by increasing dermal papilla cell proliferation and activating certain signaling pathways.
16 citations
,
December 2016 in “Molecular Medicine Reports” This study found that platelet-rich plasma may influence the proliferation of human hair dermal papilla cells by affecting gene expression related to the cell cycle.
1 citations
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June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that β-catenin stabilization in specific mammary epithelial lineages leads to cellular changes and the formation of hyperplastic lesions, revealing its role in initiating mammary neoplastic development.
May 2026 in “Frontiers in Pharmacology” In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.
January 2026 in “Frontiers in Bioscience-Landmark” This study reported that, in a laboratory setting, araliadiol derived from Centella asiatica activated antioxidant pathways, mitigating urban particulate matter-induced oxidative stress and skin damage.
January 2026 in “Food Science and Human Wellness” This study found that oral administration of Flammulina velutipes polysaccharide reduced tumor volume and improved survival in mice by modulating macrophage polarization and enhancing antitumor immune responses.
19 citations
,
April 2024 in “Journal of Umm Al-Qura University for Applied Sciences” This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.
5 citations
,
January 2012 in “Biological & Pharmaceutical Bulletin” This study found that extract of Hura crepitans inhibited androgen-accelerated NT-4 activity and ameliorated the retardation of hair regrowth in dihydrotestosterone-implanted mice, suggesting a potential role for NT-4 inhibitors in AGA.
4 citations
,
January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
12 citations
,
August 2022 in “Ecotoxicology and Environmental Safety” This study developed and validated a method using hair samples to simultaneously detect bisphenols and parabens, enabling the quantification of these endocrine disruptors in a hospital population’s hair.
10 citations
,
September 2020 in “Archives of Dermatological Research” Both methods improve hair density and thickness; double-spin may be more effective.
July 2026 in “Journal of Zhejiang University (Medical Sciences)” This study found that adipose stem cell-derived nanovesicles promoted dermal papilla cell proliferation, migration, and anti-apoptotic effects in vitro and enhanced hair follicle cycle progression in mice, primarily through activation of the β-catenin signaling pathway.
September 2025 in “Dermatology and Therapy” This systematic review and meta-analysis found that platelet-rich plasma (PRP) therapy is effective in increasing hair density and reducing hair loss for alopecia, with variations in response based on activation status.
23 citations
,
June 2016 in “FEBS Journal” The study found that up-regulating β-catenin signaling in CD 133-positive dermal papilla cells enhanced their ability to promote hair follicle regeneration both in vitro and in vivo.
17 citations
,
September 2020 in “Inflammation and Regeneration” In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
14 citations
,
April 2015 in “Stem Cell Research & Therapy” This study found that dermal stem cells from granulation tissue promoted wound healing and reduced fibrosis in a combined radiation and skin wound mouse model.
5 citations
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May 2024 in “BMC Biotechnology” This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.
1 citations
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February 2025 in “Journal of Dermatological Science” This study concluded that rapid thawing during cryoablation enhances neutrophil and lymphocyte infiltration, increases oxidative stress, and induces cell death, resulting in more substantial tissue damage in mice compared to natural thawing.
January 2022 in “Frontiers in Medical Science Research” This article discusses the perspectives of Western and Chinese medicine on alopecia areata and proposes that blood stasis may be a key factor, recommending treatments focused on blood circulation.