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Did you mean Abnormal Hair Follicles?

GlossaryAbnormal Hair Follicles

hair follicles deviating from normal structure or function

Abnormal hair follicles refer to hair follicles that deviate from their typical structure or function, often leading to issues like hair thinning, hair loss, or unusual hair growth patterns. These abnormalities can be caused by genetic factors, hormonal imbalances, autoimmune conditions, or external factors such as trauma or certain medications. For professionals, understanding the underlying cause of these abnormalities is crucial for diagnosing and treating hair-related disorders effectively.

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research Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation

30 citations, June 1993 in “The Journal of Cell Biology”

The oncoprotein causes abnormal hair growth without increasing skin cancer risk.

research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation, and Pigmentation Revealed by Molecular Profiling

9 citations, May 2012 in “PLOS ONE”

ILK is essential for skin development, pigmentation, and healing.

research Genetic Analysis of a Novel Antioxidant Multi-Target Iron Chelator, M30, Protecting Against Chemotherapy-Induced Alopecia in Mice

9 citations, February 2019 in “BMC cancer”

M30 is a promising treatment for preventing hair loss during chemotherapy.

research Trichodysplasia Spinulosa Associated with Chemotherapy for Acute Lymphocytic Leukemia

55 citations, May 2007 in “Australasian journal of dermatology”

Two boys developed a viral skin infection during chemotherapy, which resolved with improved immune function.

research Targeted Expression of SV40 T Antigen in the Hair Follicle of Transgenic Mice Produces an Aberrant Hair Phenotype

14 citations, March 1995 in “Journal of cell science”

SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.

research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables

86 citations, December 2001 in “Experimental dermatology”

Mutant mice help researchers understand hair growth and related genetic factors.

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

95 citations, July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering

57 citations, March 2013 in “Journal of Dermatological Science”

Improving the environment and cell interactions is key for creating human hair in the lab.

research Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

72 citations, November 2017 in “Journal of developmental biology”

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

research Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development

10 citations, May 2020 in “Frontiers in cell and developmental biology”

MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.

research The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted

153 citations, April 1998 in “Current Biology”

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

research A Conditional Multi-Trait Sequence GWAS Discovers Pleiotropic Candidate Genes and Variants for Sheep Wool, Skin Wrinkle, and Breech Cover Traits

11 citations, July 2021 in “Genetics selection evolution”

Researchers found genes and genetic variants linked to sheep wool and skin wrinkles.

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

9 citations, April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research Lactobacillus Paracasei HY7015 and Lycopus Lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice

3 citations, November 2022 in “Molecules/Molecules online/Molecules annual”

The substances improved hair regrowth and protected hair cells in humans and mice.

research Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep

1 citations, January 2024 in “International journal of molecular sciences”

The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.

research The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle

165 citations, September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

research The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

GRK2 is essential for healthy hair follicle function, and its absence can lead to hair loss and cysts.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations, August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations, June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations, August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Learning From Nudity: Lessons From The Nude Phenotype

86 citations, October 2005 in “Experimental Dermatology”

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

research A Pair of Transmembrane Receptors Essential for the Retention and Pigmentation of Hair

11 citations, May 2012 in “Genesis”

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH

194 citations, November 2006 in “Science”

A genetic mutation in the LIPH gene causes hair loss and growth defects.

research Neuregulin3 Alters Cell Fate in the Epidermis and Mammary Gland

39 citations, September 2007 in “BMC developmental biology”

Neuregulin3 affects cell development in the skin and mammary glands.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice

6 citations, November 2013 in “International Journal of Radiation Biology”

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.