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This review discusses the use of platelet-rich fibrin in medical fields, especially dentistry, and reports no new clinical results.

This study found that Aloe Vera, injectable platelet-rich fibrin (i-PRF), and their combination affected the proliferation of mesenchymal stem cells derived from human hair follicles, with varying concentrations tested for proliferation and cytotoxic effects.

This study found that three sessions of injectable platelet-rich fibrin (i-PRF+) significantly improved hair follicle density, hair volume, and thickness, as well as patient satisfaction in women with female pattern hair loss, with only minor self-limited adverse effects reported.

This narrative review examines the technological advancements and clinical applications of liquid injectable platelet-rich fibrin (i-PRF), discussing its use across regenerative periodontology, sports medicine, and more, as well as its potential as a drug delivery system.

In this study, I-PRF, a blood-derived biomaterial without anticoagulants, was found to inhibit melanin production and reduce oxidative stress damage in a rat model of melasma, suggesting it as a safe and cost-effective treatment option.

This case study presents a reversal of hair loss in discoid lupus erythematosus using newer treatments like injectable platelet-rich fibrin.

Platelet-rich fibrin is becoming popular for medical and cosmetic uses like hair growth and natural fillers.

This article discusses the use of platelet concentrates in regenerative surgeries for periodontal and bone defects but presents no new clinical results, emphasizing their potential benefits over traditional methods.

This review discusses the historical development of platelet-rich fibrin from fibrin glue to platelet-enriched formulations and reports no new clinical results.

In this study, researchers found that storing hair grafts at 37°C with 10% DMEM led to better graft survival compared to other solutions and temperatures, suggesting this method may enhance graft longevity and therapeutic outcomes.

Injectable Platelet Rich Fibrin effectively improves hair growth in males with hair loss.

This study found that injectable platelet-rich fibrin significantly improved hair growth and patient satisfaction as a cost-effective adjuvant treatment for androgenetic alopecia.

This review of 47 studies indicates that platelet preparations may significantly enhance cellular activity, wound healing, and facial aesthetic outcomes in facial plastic surgery, though potential publication bias should be considered.

This study observed that a treatment combining platelet-rich fibrin and micrograft spray-on skin led to rapid and complete wound healing in both massive and chronic burn patients within an average of 7-10 days.

This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.

This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.

This review discusses the use of non-transfusional hemocomponents in surgical procedures for tissue regeneration and reports no new empirical findings.

This review discusses the evolution of platelet concentrates in regenerative medicine, highlighting a proposed function-driven classification that distinguishes three generations of PCs by biological activity rather than development order, with third-generation exosome-based therapies showing superior therapeutic efficacy over earlier formulations.

This review suggests that PRF may be a promising alternative treatment for oral mucosal lesions, but further research is needed to confirm its long-term effectiveness and standardize preparation protocols.

In this study, platelet-rich fibrin matrix combined with follicular unit transplantation increased hair follicle numbers in men with androgenetic alopecia on the treated side of the scalp after six months.

This study investigated different centrifugation systems and found that low-speed protocols and certified centrifuges produced better-quality platelet-rich fibrin and recommended using FDA-approved glass tubes for safe and effective regenerative outcomes.

In this study, significant improvements in skin density and thickness, especially around the lower eyelid, were observed across all age groups using plasma fractions from a single blood draw, indicating that the therapy's effectiveness may be age-independent.

This study reviews various factors affecting mesenchymal stem cell transplantation efficacy, including platelet concentrate composition, donor characteristics, and environmental influences, and examines strategies for optimizing outcomes through preconditioning and combined therapies in regenerative medicine.

This study constructed a model using serum levels of BMP2, CD8A, PRF1, and XCL1 as a non-invasive biomarker to accurately predict recurrence in patients with alopecia areata.

In this case report, pulsed radiofrequency neuromodulation provided over 80% pain relief for five months in a patient with chronic lesser occipital nerve pain after other treatments failed.

In this animal study, PRF enhanced the repair of chronic wounds in rats by reducing inflammation and promoting collagen deposition and new blood vessel formation, potentially through activating the Wnt/β-catenin signaling pathway.

This study found that platelet-rich fibrin provides more sustained therapeutic effects than platelet-rich plasma in inhibiting apoptosis and enhancing proliferation and migration of human endometrial stromal cells.

This study found significant variability in the production and use of platelet-rich plasma and related products in Brazil, highlighting the need for regulatory measures to ensure safety.

This review covers the use of platelet-rich plasma in dermatology for wound healing, hair restoration, skin rejuvenation, and dermal augmentation, and notes the need for standardized guidelines.

In this narrative review, the authors discuss regenerative substances like platelet-rich fibrin and mesenchymal stem cells in biological aesthetics, noting that while these methods show promise for regeneration, their safety, effectiveness, and durability remain uncertain due to limited and heterogeneous evidence.