38 citations
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April 2018 in “Diseases” This study observed that fibrin rich in leukocytes and platelets (L-PRF) might effectively heal diabetic foot ulcers with osteomyelitis, showing positive preliminary results in all three patients treated.
23 citations
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December 2021 in “International Journal of Environmental Research and Public Health” This study found that advanced platelet-rich fibrin (A-PRF) reduced postoperative complications like pain, trismus, and edema following mandibular wisdom teeth removal.
23 citations
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September 2020 in “Journal of Cosmetic Dermatology” This review discusses the potential applications of injectable platelet‐rich fibrin in various conditions and reports no new clinical results; the authors highlight its favorable use in comparison to existing treatments.
16 citations
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July 2018 in “Dermatologic Surgery” In this study, iL-PRF injections produced significantly better clinical scores for androgenetic alopecia patients compared to controls, especially in those with more severe baseline conditions.
5 citations
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April 2025 in “Journal of Functional Biomaterials” In this study, the addition of A-PRF+ to surgical protocols significantly improved bone healing and implant stability when combined with biomaterials, suggesting it as a viable option for patients concerned about using human- and animal-derived biomaterials.
April 2026 in “Journal of Dermatological Treatment” This study concluded that in female pattern hair loss patients, CGF and i-PRF treatments were more effective than PRP in increasing target area hair count, with i-PRF having the lowest adverse event rate.
June 2025 in “Journal of medical and dental science research.” This article explores the potential of platelet-rich fibrin therapies for androgenetic alopecia and highlights their possible advantages over traditional treatments without reporting new clinical results.
May 2025 in “Journal of medical and dental science research.” This article discusses the potential role and mechanisms of platelet-rich fibrin therapies in androgenetic alopecia management, exploring their possible benefits over existing treatments but reports no new clinical results.
February 2025 in “Archives of Dermatological Research” In this study, researchers administered injectable platelet-rich fibrin (i-PRF) to 30 patients with androgenetic alopecia, finding an 80% response rate after 6 months, with improved hair density and reduced scalp symptoms, while reporting minimal adverse reactions.
July 2023 in “Research Square (Research Square)” In an in-vitro study, researchers found that a specific concentration of Aloe Vera combined with injectable platelet-rich fibrin (i-PRF) significantly increased hair follicle stem cell proliferation compared to Aloe Vera or i-PRF alone, indicating potential benefits for alopecia treatment.
August 2026 in “Journal of Maxillofacial and Oral Surgery” This study investigated treatments for male androgenetic alopecia, finding that combining injectable platelet-rich fibrin (i-PRF) with microneedling increased hair growth more effectively than i-PRF alone according to questionnaires and photographic assessments.
March 2026 in “Frontiers in Pharmacology” The study concluded that the Exprecell™ device for preparing anticoagulant-free f-PRF increases volume yield and simplifies the process while maintaining biological activity comparable to conventional methods, suggesting potential clinical utility.
February 2026 in “Trends in Sciences” In a testosterone-induced mouse model, this study found that exosomes from injectable Platelet-Rich Fibrin (i-PRF) significantly reduced inflammation, oxidative stress, and apoptosis, while enhancing hair regeneration, with the greatest improvements seen when combined with minoxidil, suggesting potential as a novel treatment for androgenetic alopecia.
December 2024 in “Biological and Clinical Sciences Research Journal” In this study, injectable platelet-rich fibrin (I-PRF) was found to be more effective than platelet-rich plasma (PRP) at improving hair growth outcomes and patient satisfaction for androgenic alopecia.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers used a computational drug repurposing approach to identify FDA-approved drugs Dutasteride and Solifenacin as potential inhibitors of Listeria monocytogenes via binding to the virulence factor regulator PrfA, suggesting they may offer new treatment strategies against multi-drug resistant strains.
25 citations
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May 2014 in “Facial Plastic Surgery” In this study, intradermal injections of autologous platelet-rich fibrin matrix significantly increased hair density in patients with androgenetic alopecia at 2 and 3 months after initial treatment.
7 citations
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March 2024 in “Veterinary Medicine and Science” In this study, eight dogs with naturally occurring skin wounds were treated with autologous platelet-rich fibrin therapy, which significantly promoted wound healing and tissue regeneration without using additional medications, leading to promising outcomes and minimal scarring.
2 citations
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July 2024 in “Bioengineering” This study found that platelet-rich fibrin lysates modulate chemokine expression, reducing inflammation in oral squamous carcinoma cells, but increasing expression in primary oral epithelial cells.
1 citations
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December 2022 in “Archives of Dermatological Research” This study compared fluid PRF and PRP for treating atrophic acne scars and found PRF to be more effective, particularly when combined with needling. Both treatments improved scars, but PRF showed higher therapeutic response, suggesting it as a superior alternative for acne scar treatment.
September 2023 in “International Journal of Science and Research (IJSR)” In this case study, PRP and PRF treatments helped achieve complete healing of chronic wounds, including a chemical burn ulcer in three weeks and a pilonidal sinus post-incision in eight weeks, suggesting potential benefits for chronic wound management.
April 2022 in “The Egyptian Journal of Hospital Medicine” This review examines the use of platelet rich fibrin for treating post-acne scars and reports no new clinical results; it highlights that fibrin's matrix enables a prolonged release of growth factors.
January 2021 in “Hair therapy & transplantation” This study reports encouraging results in treating androgenetic alopecia by combining injectable PRF and PDO thread insertion on the scalp.
March 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” In this study, L-PRF was associated with successful osseointegration and tissue healing when used with biomaterial for dental implants in a patient with an atretic bone ridge.
18 citations
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January 2019 in “International journal of trichology” This study found that injectable platelet-rich fibrin (i-PRF) showed improved hair growth in males with Type VI and Type VII alopecia, which are typically difficult to treat.
13 citations
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June 2016 in “Journal of neurological surgery” This study suggests that leukocyte-platelet-rich fibrin membranes may aid postoperative healing in endoscopic skull base surgery, with some patients showing reduced crusting and low rates of cerebrospinal fluid leaks.
11 citations
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August 2025 in “Journal of Periodontal Research” This review highlights that autologous platelet concentrates, particularly platelet-rich fibrin, have shown potential to enhance healing and outcomes in both dental and medical applications, including injury recovery and aesthetics.
4 citations
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April 2024 in “Cellular and Molecular Biology” In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
4 citations
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October 2020 in “Journal of oral and maxillofacial surgery” This review discusses the use of Tisseel for stabilizing particulate grafts and reports no new clinical results; the authors emphasize the need for further controlled trials.
2 citations
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January 2023 in “Eastern Journal Of Medicine” This review discusses the use, efficiency, and preparation methods of autologous platelet concentrates in wound healing and periodontal regeneration, but it reports no new clinical findings.
2 citations
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October 2021 in “Experimental Cell Research” This study found that injectable platelet-rich fibrin (i-PRF) enhances hair follicle regeneration in vitro by promoting human dermal papilla cell proliferation, migration, and trichogenic inductivity, with varying effects depending on concentration.