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    Glossary β-catenin

    protein involved in cell signaling and hair follicle regulation

    β-catenin is a protein that plays a crucial role in cell signaling and the regulation of cell growth and development. It is a key component of the Wnt signaling pathway, which is important for processes like embryonic development and the maintenance of adult tissues, including hair follicles. Abnormal β-catenin activity is associated with various conditions, including cancer and hair loss disorders like alopecia.

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    1. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice Genes & Development · 2008 · 556 citations
    2. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells Genes & development · 2005 · 384 citations
    3. Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours Development · 2004 · 335 citations
    4. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    5. Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair The EMBO Journal · 2011 · 248 citations
    6. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    7. Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate Development · 2008 · 193 citations
    8. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006 · 147 citations
    9. Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin Development · 2011 · 128 citations
    10. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF Nature Communications · 2017 · 117 citations
    11. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages Nature Communications · 2016 · 115 citations
    12. Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice Journal of Ethnopharmacology · 2011 · 91 citations
    13. Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect Journal of Dermatological Science · 2011 · 88 citations
    14. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing Development · 2016 · 87 citations
    15. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    16. SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells Stem Cell Reports · 2017 · 77 citations
    17. β-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes during Post-Traumatic Gliogenesis in the Adult Brain Stem Cells · 2009 · 67 citations
    18. Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling Science Advances · 2020 · 65 citations
    19. Fibroblast Growth Factors Stimulate Hair Growth through<i>β</i>-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015 · 64 citations
    20. Role of  -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer Cold Spring Harbor Symposia on Quantitative Biology · 2008 · 61 citations
    21. miR‐218‐5p regulates skin and hair follicle development through Wnt/β‐catenin signaling pathway by targeting SFRP2 Journal of cellular physiology · 2019 · 54 citations
    22. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity Cell reports · 2016 · 54 citations
    23. Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling Development · 2009 · 54 citations
    24. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    25. Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 49 citations
    26. Skin tumors with matrical differentiation: lessons from hair keratins, beta‐catenin and PHLDA‐1 expression Journal of Cutaneous Pathology · 2014 · 47 citations
    27. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    28. 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    29. Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation Developmental Biology · 2010 · 43 citations
    30. β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid Aging · 2019 · 42 citations