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Sex and race affect immune responses and treatment outcomes in Hidradenitis suppurativa.

Gut microbiota influences the development of alopecia areata.

This study found that DEB-BACE combined with systemic chemotherapy was more effective than chemotherapy alone for unresectable lung squamous cell carcinoma, reducing side effects and improving survival rates.

This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.

This study found that trichoscopic quantitative parameters reliably indicate the severity of female pattern hair loss and complement the Sinclair scale by offering a more objective and reproducible grading system.

This study observed that triple horizontal scalp biopsies provided a more accurate diagnosis of female pattern hair loss in women than a single horizontal biopsy, especially for those with advanced hair loss.

This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.

This study found that obesity in PCOS women with biochemical hyperandrogenemia lowers androstenedione levels and increases the testosterone to androstenedione ratio, but this was not observed in women with clinical hyperandrogenemia or in controls.

This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.

This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.

Expanding regulatory T cells may help treat alopecia areata by reducing harmful immune cells.

This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.

In a murine model of alopecia areata, this study observed that the IL-2 fusion protein HCW9302 helped prevent disease development by expanding regulatory T cells and reducing disease-causing effector T cell infiltrates, suggesting potential for using IL-2 fusion proteins in alopecia areata treatment.

Increased Treg cells and IL-10 may help quick recovery in acute diffuse and total alopecia.

Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.

ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

This study found that Th22 cells and their cytokine IL-22 may play an important role in the pathogenesis of systemic lupus erythematosus and could serve as bioindicators for monitoring disease severity.

This study found that combining hair transplantation with platelet-rich plasma treatment significantly improved hair regeneration, reduced hair loss, and minimized skin lesion areas in patients with androgenic alopecia compared to hair transplantation alone, suggesting enhanced treatment efficacy.

In this study, women with PCOS who had children reported shorter menstrual cycles and more regular daily routines compared to childless women, who experienced less hirsutism and weight gain.

This article hypothesizes that thymoma with aplastic anemia may result from abnormal autoimmune CD8⁺ T lymphocytes produced by the thymoma, potentially leading to other cytotoxic T-cell-mediated autoimmune diseases.

In this study, researchers found that nearly half of Korean women with female pattern hair loss showed temporal scalp involvement, with a decrease in temporal hair density compared to occipital areas.

This source describes a previous case report that combined anthralin and calcipotriene to treat alopecia areata, showing promising results, but highlights that further research is needed to understand the mechanisms and potential benefits of this combination therapy.

In this study, a topical hair growth serum containing ingredients like procapil and redensyl was found to be safe and effective for subjects with androgenic alopecia, significantly improving hair density, thickness, and Anagen:Telogen ratio after 120 days, with no observed adverse effects.

This study found that an ethanolic extract of Ganoderma lucidum, especially at 15mg/kg, may promote hair growth in a rat model of testosterone-induced alopecia, showing effects comparable to minoxidil.

Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.

This review discusses how recent studies use models and experiments to understand immune system signaling, but it reports no new clinical findings; the authors suggest strategies for improving these models.

This study found that zinc treatment in alopecia areata patients may increase CD8+ cells, suggesting its effectiveness could be due to immunomodulation.

This animal study observed that treatment with the S1PR modulator NXC736 significantly reduced lesion area and CD8+ T cell infiltration in mice with alopecia areata, suggesting its potential as a promising therapy for the condition.

This study found that administering an S1PR 1&4 modulator reduced alopecia areata lesion size and decreased CD8+ T cell infiltration in mice, suggesting potential as a treatment for this condition.