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    Glossary Sandalore

    synthetic sandalwood odorant that promotes hair growth

    Sandalore is a synthetic sandalwood odorant that has been found to have biological effects beyond its use in perfumery. Research has shown that Sandalore can activate olfactory receptors in the skin, specifically OR2AT4, which can promote hair growth and wound healing by stimulating keratinocyte proliferation and migration. This makes it a compound of interest in dermatology and trichology for potential therapeutic applications.

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    Research 30 of 34

    1. Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore<sup>®</sup>, improves telogen effluvium‐associated parameters Journal of Cosmetic Dermatology · 2020 · 11 citations
    2. 181 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates telogen effluvium: Randomized, double-blinded, placebo-controlled trial Journal of Investigative Dermatology · 2019
    3. 609 Topical Sandalore®, a specific OR2AT4-stimulating odorant, ameliorates female telogen effluvium: Randomized, double-blinded, placebo-controlled clinical trial Journal of Investigative Dermatology · 2019
    4. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    5. OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes Antioxidants · 2022 · 6 citations
    6. A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia? Biomedicines · 2021 · 4 citations
    7. New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies Italian journal of dermatology and venereology · 2018 · 3 citations
    8. 219 STAT5 activation in the dermal papilla is important for hair follicle growth phase induction, hair follicle regeneration and wound healing Journal of Investigative Dermatology · 2016 · 1 citations
    9. 184 WITHDRAWN Journal of Investigative Dermatology · 2019
    10. 185 Infrared and high frequency ultrasound imaging of skin lesions in atopic dermatitis and psoriasis vulgaris Journal of Investigative Dermatology · 2019
    11. 495 OR2AT4 activation by a synthetic odorant, stimulates dermcidin production in human hair follicle epithelium and increases follicular resistance to bacterial contamination: A novel antimicrobial folliculitis therapy? 2019
    12. 216 Human hair follicles can “smell”: OR2AT4-mediated hair growth regulation Journal of Investigative Dermatology · 2016
    13. 182 Retinol remarkably effective in reducing neck wrinkles Journal of Investigative Dermatology · 2019
    14. 217 The adenosine-generating ecto-enzyme CD73 regulates human hair growth Journal of Investigative Dermatology · 2016
    15. 218 Chemokine receptor CCR5 is the novel target for the treatment of alopecia areata Journal of Investigative Dermatology · 2016
    16. Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options Expert Opinion on Therapeutic Targets · 2019 · 19 citations
    17. Pathobiology questions raised by telogen effluvium and trichodynia in COVID‐19 patients Experimental Dermatology · 2021 · 18 citations
    18. 608 A clinical study to test the efficacy of VB1953 in clindamycin non-responder acne patients with antibiotic-resistant P. acnes Journal of Investigative Dermatology · 2019 · 1 citations
    19. 605 Efficacy and safety of dupilumab in adolescent patients with moderate-to-severe atopic dermatitis Journal of Investigative Dermatology · 2019 · 1 citations
    20. 606 The role of diet in patients with autoimmune blistering disease: A survey of the International Pemphigus and Pemphigoid Foundation Journal of Investigative Dermatology · 2019
    21. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    22. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    23. Selective isomerization of α-pinene oxide to campholenic aldehyde by ionic liquid-supported indenyl-molybdenum(II)-bipyridine complexes Journal of Organometallic Chemistry · 2022 · 6 citations
    24. Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion Molecular Therapy — Nucleic Acids · 2025
    25. Beta-caryophyllene enhances wound healing through multiple routes PloS one · 2019 · 67 citations
    26. Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis Biomedicines · 2020 · 26 citations
    27. Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall Clinical, cosmetic and investigational dermatology · 2020 · 14 citations
    28. Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases Cell Biology and Toxicology · 2024 · 4 citations
    29. A Novel, Drinkable Food Supplement Formulation Reduces Hair Shedding and Increases the Percentage of Anagen Scalp Hair Follicles in Females with Hair Loss Journal of Clinical Medicine · 2025
    30. Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium International Journal of Trichology · 2025