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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

Increased PPARGC1α relates to hair thinning in common baldness.

Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Female pattern hair loss is common, linked to polycystic ovarian syndrome, and treated with topical Minoxidil.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

PRP treatment may promote hair growth and improve hair density in women with AGA, but more research is needed.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Stephen Rothman made important discoveries in dermatology, including the use of PABA in sunscreens, but never profited from his work.

Blocking a specific enzyme can reduce the negative impact of stress hormones on hair growth cells.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

The Siah1 and Siah2 genes are active in mouse skin development and hair growth, especially right after birth.

Certain miRNAs might be involved in a hair loss condition called frontal fibrosing alopecia and could possibly help in its diagnosis.

The study found that sweat glands normally suppress immune responses, but this is disrupted in certain skin diseases, possibly contributing to their development.

Men and women experience skin aging differently due to changes in sex hormone levels with age.