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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

A new compound effectively inhibits human 5α-reductase 1.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Finasteride may affect PNMT, causing side effects.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Licorice extract helps hair growth and may treat hair loss.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Both drugs lower DHT levels, with GI198745 being more effective.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

A new anti-baldness patch effectively treats hair loss by blocking enzymes linked to the condition.

Glioblastoma cells can make androgens, which might help the tumor grow.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

5-alpha reductase inhibitors may reduce bladder cancer recurrence and improve survival.

Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.

The document concludes that individualized treatments for hair issues are effective, certain hair changes can indicate neurocutaneous diseases, specific lotions improve skin health, laser hair removal works but needs more study on long-term effects, men's cosmetics are diverse, peeling is effective but can have side effects, and facial pigmentation is often due to overactive skin cells.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.