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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

DHT, a testosterone byproduct, causes male pattern baldness.

Men with liver cancer have higher levels of a specific testosterone byproduct in their liver and blood, despite overall lower male hormone levels.

Women with acne have lower levels of a specific hormone marker than women without acne.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

New tests detect finasteride and dutasteride in urine quickly and easily.

Finasteride lowers DHT levels and raises testosterone in a dose-dependent way.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

Treatment during development affects hormone balance and sexual behavior in male rats.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

People with hair loss may have different levels of certain hormones due to changes in hormone processing.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Finasteride helps reduce blood vessel growth in diabetic rat kidneys.

Testosterone is crucial for development, growth, and various body functions in mammals.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Finasteride affects prostate weights and pituitary activity differently with age.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.